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Osteoporotic hip fractures in non-elderly patients: relevance of associated co-morbidities

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Abstract

Osteoporotic hip fractures (OHF) are not limited to elderly; however, studies in non-elderly are scarce. Thus, the aim of this study was to evaluate co-morbidities in non-elderly patients with OHF in a Community Teaching Hospital. All hospitalizations due to OHF during a 3-year period in a Community Teaching Hospital were retrospectively evaluated for co-morbidities, and patients 18–64 years old were compared with those ≥65 years old. Of all hospitalizations, 232 (0.73%) were due to hip fractures, and 120/232 (51.7%) patients had OHF. The comparison of the 13 (10.8%) OHF patients <65 years old (47.3 ± 9.7 years) with 107 (89.2%) ≥65 years old (80.4 ± 7.7 years) revealed a male predominance (61.5 vs. 27.1%, P = 0.022) and a distinct ethnic distribution with a lower proportion of Caucasians in the former (61.5 vs. 86.9%, P = 0.033). Moreover, non-elderly OHF patients had higher frequencies of insulin-dependent DM (38.5 vs. 3.7%, P = 0.001) and alcoholism (38.5 vs. 4.7%, P = 0.001) than aged patients. In contrast, rates of age-related co-morbidities such as stroke (7.7 vs. 18.7%, P = 0.461), heart failure (23.1 vs. 14.0%, P = 0.411), and dementia (7.7 vs. 15.9%, P = 0.689) were comparable in both groups. Logistic regression analysis demonstrated that insulin-dependent DM (OR = 25.4, 95% CI = 4.7–136.8, P < 0.001) and alcoholism (OR = 20.3, 95% CI = 3.9–103.3, P < 0.001) remained as independent risk factors for OHF in non-elderly patients. Osteoporosis is an important cause of HF in Community Hospital. Non-elderly patients with OHF have a peculiar demographic profile and associated co-morbidities. These findings reinforce the need of early osteoporosis diagnosis and rigorous fracture prevention in patients with DM and alcoholism.

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Authors and Affiliations

  1. Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo 455, 3° Andar, Sala 3190, São Paulo, SP, 01246-903, Brazil

    Sandra G. Pasoto, Eloisa Bonfa & Rosa M. R. Pereira

  2. Division of Internal Medicine, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brazil

    Liz A. K. Yoshihara, Lucy C. Maeda, Marcia M. S. Bernik & Paulo A. Lotufo

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  1. Sandra G. Pasoto
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  2. Liz A. K. Yoshihara
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  3. Lucy C. Maeda
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  4. Marcia M. S. Bernik
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  5. Paulo A. Lotufo
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  6. Eloisa Bonfa
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  7. Rosa M. R. Pereira
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Correspondence to Sandra G. Pasoto.

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Pasoto, S.G., Yoshihara, L.A.K., Maeda, L.C. et al. Osteoporotic hip fractures in non-elderly patients: relevance of associated co-morbidities. Rheumatol Int 32, 3149–3153 (2012). https://doi.org/10.1007/s00296-011-2154-x

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  • DOI: https://doi.org/10.1007/s00296-011-2154-x

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