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Diagnostic value of anti-cyclic citrullinated peptide antibody for rheumatoid arthritis in a Chinese population: a meta-analysis

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Abstract

To use meta-analysis to determine the accuracy of anti-cyclic citrullinated peptide (CCP) antibody in diagnosis of patients with rheumatoid arthritis (RA) in a Chinese population, we searched MEDLINE and CNKI databases for studies published in English or Chinese between January 2000 and June 2010. Two investigators independently evaluated studies for inclusion, data extraction, and quality assessment. We used a random-effects model to combine estimates of sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR−), and diagnostic odds ratio (DOR). One hundred and eighteen studies met our inclusion criteria. All studies were of high quality. The summary estimates for anti-CCP antibody in the diagnosis of RA in a Chinese population were as follows: sensitivity 0.65 (95% confidence interval (CI) 0.65–0.66), specificity 0.95 (95% CI 0.95–0.96), positive likelihood ratio (LR+) 15.84 (95% CI 13.55–18.54), negative likelihood ratio (LR−) 0.33 (95% CI 0.31–0.35), and diagnostic odds ratio (DOR) 51.60 (95% CI 43.64–61.01). With high specificity and moderate sensitivity, anti-CCP antibody tests play an important role in conforming the diagnosis of RA in a Chinese population.

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Acknowledgments

Thanks to M. M. Jiayong Liu for his assistance in statistical analysis.

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Authors and Affiliations

  1. Department of Laboratory Medicine, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xue Fu Road, Harbin, 150086, China

    Fei Gao, Lei Ren, Cai-Qin Zhang, Feng-Yun Mu, Yan-Qiu You & Yan-Hong Liu

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  1. Fei Gao
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  2. Lei Ren
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  3. Cai-Qin Zhang
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Correspondence to Yan-Hong Liu.

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The authors Fei Gao and Lei Ren equally contributed to this study.

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Gao, F., Ren, L., Zhang, CQ. et al. Diagnostic value of anti-cyclic citrullinated peptide antibody for rheumatoid arthritis in a Chinese population: a meta-analysis. Rheumatol Int 32, 3201–3218 (2012). https://doi.org/10.1007/s00296-011-2153-y

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