Abstract
Although Behçet’s disease (BD) is a kind of systemic disease, renal involvement is rare, especially IgA nephropathy (IgAN). Renal manifestations in BD range from mild urinary abnormalities to glomerulonephritis with persistent renal failure, which includes minimal change disease, proliferative glomerulonephritis, rapidly crescentic glomerulonephritis, renal amyloidosis and IgA nephropathy. Amyloidosis seems to be the most common type of renal lesion in BD, and several cases of nephrotic syndrome secondary to amyloidosis have been documented. Co-occurrence of BD and IgA nephropathy has only been reported in only few cases. We describe two patients with the rare association of BD and IgAN. We suggested that it is important to periodically perform renal function assessment in patients with BD, through urinalysis and measurement of serum creatinine for detecting any abnormality and providing an early adequate treatment.
References
Lightfoot RW Jr (1992) Behcet’s syndrome. In: McCarthy DJ, Koopman WJ (eds) Arthritis and allied conditions. Lea and Febiger, Philadelphia, pp 1130–1134
Yazici H (1994) Behcet’s syndrome. In: Klippel JH, Dieppe PA (eds) Rheumatology. London: Mosby: 6.20.1–6
Altıparmak MR, Tanverdi M, Pamuk ON, Tunc R, Hamuryudan V (2002) Glomerulonephritis in behcet’s disease: report of seven cases and review of the literature. Clin Rheumatol 21:14–18
Malik GH, Sirwall IA, Pandit KA (1989) Behcet’s syndrome associated with minimal change glomerulonephritis and renal vein thrombosis. Nephron 52:87–89
El Ramahi KM, Al Dalan A, Al Shaikh A, Al Meshari K, Akhtar M (1998) Renal involvement in Behcet’s disease: review of 9 cases. J Rheumatol 25:2254–2260
Kim SD, Kim SH, Kim HR et al (2005) Rapidly-progressive glomerulonephritis in a patient with Behcet’s disease: successful treatment with intravenous cyclophosphamide. Rheumatol Int 25:540–542
Akiyama Y, Suzuki T, Tanaka M et al (1995) A case of Behcet’s disease associated with aortic regurgitation and nephrotic syndrome. Ryumachi 35:910–914
Akpolat T, Diri B, Oguz Y, Yilmaz E, Yavuz M, Dilek M (2003) Behcet’s disease and renal failure. Nephrol Dial Transplant 18:888–891
Hemmen T, Perez-Canto A, Distler A, Offerman G, Braun J (1997) IgA nephropathy in a patient with Behcet’s syndrome: case report and review of literature. Br J Rheumatol 36:696–699
Akutsu Y, Itami N, Tanaka M, Kusunoki Y, Tochimaru H, Takekoshi Y (1990) IgA nephritis in Behcet’s disease: case report and review of the literature. Clin Nephrol 34:52–55
Fernandes PF, Junior GB, Barros FA, Sousa DC, Franco LM, Patroci-nio RM (2006) Behcet’s disease and IgA nephropathy: report of this association in a patient from Brazil and literature review. Invest Clin 47:405–411
Donadio JV, Grande JP (2002) IgA nephropathy. N Engl J Med 347:738–748
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Altay, M., Secilmis, S., Unverdi, S. et al. Behcet’s disease and IgA nephropathy. Rheumatol Int 32, 2227–2229 (2012). https://doi.org/10.1007/s00296-011-2051-3
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DOI: https://doi.org/10.1007/s00296-011-2051-3