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Behcet’s disease and IgA nephropathy

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Abstract

Although Behçet’s disease (BD) is a kind of systemic disease, renal involvement is rare, especially IgA nephropathy (IgAN). Renal manifestations in BD range from mild urinary abnormalities to glomerulonephritis with persistent renal failure, which includes minimal change disease, proliferative glomerulonephritis, rapidly crescentic glomerulonephritis, renal amyloidosis and IgA nephropathy. Amyloidosis seems to be the most common type of renal lesion in BD, and several cases of nephrotic syndrome secondary to amyloidosis have been documented. Co-occurrence of BD and IgA nephropathy has only been reported in only few cases. We describe two patients with the rare association of BD and IgAN. We suggested that it is important to periodically perform renal function assessment in patients with BD, through urinalysis and measurement of serum creatinine for detecting any abnormality and providing an early adequate treatment.

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References

  1. Lightfoot RW Jr (1992) Behcet’s syndrome. In: McCarthy DJ, Koopman WJ (eds) Arthritis and allied conditions. Lea and Febiger, Philadelphia, pp 1130–1134

    Google Scholar 

  2. Yazici H (1994) Behcet’s syndrome. In: Klippel JH, Dieppe PA (eds) Rheumatology. London: Mosby: 6.20.1–6

  3. Altıparmak MR, Tanverdi M, Pamuk ON, Tunc R, Hamuryudan V (2002) Glomerulonephritis in behcet’s disease: report of seven cases and review of the literature. Clin Rheumatol 21:14–18

    Article  PubMed  Google Scholar 

  4. Malik GH, Sirwall IA, Pandit KA (1989) Behcet’s syndrome associated with minimal change glomerulonephritis and renal vein thrombosis. Nephron 52:87–89

    Article  PubMed  CAS  Google Scholar 

  5. El Ramahi KM, Al Dalan A, Al Shaikh A, Al Meshari K, Akhtar M (1998) Renal involvement in Behcet’s disease: review of 9 cases. J Rheumatol 25:2254–2260

    PubMed  CAS  Google Scholar 

  6. Kim SD, Kim SH, Kim HR et al (2005) Rapidly-progressive glomerulonephritis in a patient with Behcet’s disease: successful treatment with intravenous cyclophosphamide. Rheumatol Int 25:540–542

    Article  PubMed  Google Scholar 

  7. Akiyama Y, Suzuki T, Tanaka M et al (1995) A case of Behcet’s disease associated with aortic regurgitation and nephrotic syndrome. Ryumachi 35:910–914

    PubMed  CAS  Google Scholar 

  8. Akpolat T, Diri B, Oguz Y, Yilmaz E, Yavuz M, Dilek M (2003) Behcet’s disease and renal failure. Nephrol Dial Transplant 18:888–891

    Article  PubMed  CAS  Google Scholar 

  9. Hemmen T, Perez-Canto A, Distler A, Offerman G, Braun J (1997) IgA nephropathy in a patient with Behcet’s syndrome: case report and review of literature. Br J Rheumatol 36:696–699

    Article  PubMed  CAS  Google Scholar 

  10. Akutsu Y, Itami N, Tanaka M, Kusunoki Y, Tochimaru H, Takekoshi Y (1990) IgA nephritis in Behcet’s disease: case report and review of the literature. Clin Nephrol 34:52–55

    PubMed  CAS  Google Scholar 

  11. Fernandes PF, Junior GB, Barros FA, Sousa DC, Franco LM, Patroci-nio RM (2006) Behcet’s disease and IgA nephropathy: report of this association in a patient from Brazil and literature review. Invest Clin 47:405–411

    PubMed  Google Scholar 

  12. Donadio JV, Grande JP (2002) IgA nephropathy. N Engl J Med 347:738–748

    Article  PubMed  CAS  Google Scholar 

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The authors declare that they have no conflict of interest.

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Correspondence to Mustafa Altay.

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Altay, M., Secilmis, S., Unverdi, S. et al. Behcet’s disease and IgA nephropathy. Rheumatol Int 32, 2227–2229 (2012). https://doi.org/10.1007/s00296-011-2051-3

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  • DOI: https://doi.org/10.1007/s00296-011-2051-3

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