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Association of rheumatoid arthritis risk with EGFR genetic polymorphisms in Taiwan’s Han Chinese population

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Abstract

The involvement of the epidermal growth factor receptor (EGFR) in the pathogenesis of cancer is well documented. In contrast, its role in rheumatoid arthritis (RA) development is not that well defined although previous studies suggested the possible link between autoimmune diseases and malignancy. Therefore, we aimed to examine whether there is a link between the EGFR genetic polymorphisms and the RA. Our study gauged the effects of EGFR (rs11543848 and rs17337023) single-nucleotide polymorphisms (SNPs) on RA among Taiwan’s Han Chinese population. Polymorphism of EGFR gene was analyzed in 188 RA patients and 128 control subjects. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. Our data confirmed statistically significant increased risk of RA development in subjects with A carrier at rs17337023 SNP (P < 0.0001), and subjects with A allele at rs17337023 SNP (odds ratio [OR] = 1.52; 95% confidence interval [CI] = 1.10–2.09). Furthermore, comparison of haplotype frequencies between patients and controls suggested GA and AT haplotypes were more “at-risk” for RA development (P < 0.0001 and P < 0.01, respectively). However, comparisons of the clinical features of RA patients according to different genotypes and haplotypes revealed no significant difference. In conclusion, our data yield the new information on EGFR polymorphisms (rs11543848 and rs17337023) with the susceptibility of RA development and polymorphism revealed by this study merit further investigation.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung, Taiwan

    Sui-Foon Lo

  2. Department of Medical Genetics, China Medical University Hospital, No. 2, Yuh Der Road, Taichung, Taiwan

    Lei Wan, Shih-Yin Chen, Su-Ching Liu & Fuu-Jen Tsai

  3. Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

    Chung-Ming Huang

  4. Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan

    Fuu-Jen Tsai

  5. Department of Physical Therapy, China Medical University Hospital, Taichung, Taiwan

    Hsiu-Chen Lin

  6. Department of Chinese Medicine, China Medical University Hospital, Taichung, Taiwan

    Sui-Foon Lo

  7. Graduate Institute of Chinese Medical Science, China Medical University Hospital, Taichung, Taiwan

    Lei Wan, Shih-Yin Chen & Fuu-Jen Tsai

  8. Graduate Institute of Integrated Medicine, China Medical University Hospital, Taichung, Taiwan

    Chung-Ming Huang

  9. Department of Biotechnology, Asia University, Taichung, Taiwan

    Fuu-Jen Tsai

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  1. Sui-Foon Lo
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  2. Lei Wan
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  4. Chung-Ming Huang
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  7. Fuu-Jen Tsai
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Correspondence to Fuu-Jen Tsai.

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Lo, SF., Wan, L., Lin, HC. et al. Association of rheumatoid arthritis risk with EGFR genetic polymorphisms in Taiwan’s Han Chinese population. Rheumatol Int 32, 2301–2306 (2012). https://doi.org/10.1007/s00296-011-1961-4

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  • DOI: https://doi.org/10.1007/s00296-011-1961-4

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