Abstract
Psoriasis and psoriatic arthritis (PsA) is a complex autoimmune disease. NOD2/CARD15 gene has been suggested to play an important role in the pathogenesis of psoriasis and PsA. This study aims to assess the association between NOD2/CARD15 polymorphisms and the susceptibility to psoriasis/PsA. A meta-analysis was performed to survey studies on the NOD2/CARD15 polymorphisms and psoriasis/PsA using comprehensive PubMed, Embase, and Web of Science citation search. A total of 9 published studies were involved. Meta-odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models were depended on Cochran’s Q-statistic. Potential publication bias was evaluated by Egger’s linear regression test. As for R702W, the pooled ORs were 1.041 (95% CI 0.854–1.268, P = 0.693; 2,081 patients vs. 2,717 controls) for C allele and 0.886 (95% CI 0.565–1.391. P = 0.600; 1,222 patients vs. 1,818 controls) for genotype. Then for G908R, the pooled ORs were 1.042 (95% CI, 0.761–1.426, P = 0.799; 2,053 patients vs. 2,743 controls) for C allele and 0.942 (95% CI 0.708–1.254, P = 0.683; 1,226 patients vs. 1,824 controls) for the homozygous wild type. Then for Leu1007fsinsC allele polymorphism and genotype, the pooled ORs were 1.160 (95% CI, 0.893–1.507, P = 0.266; 2,279 patients vs. 3,067 controls) and 1.266 (95% CI 0.897–1.789, P = 0.180; 1,979 patients vs. 1,607 controls), respectively. No obvious publication bias was shown in the results. The association between NOD2/CARD15 polymorphisms and psoriasis/PsA was not found. Taken together, our results suggest that NOD2/CARD15 might not be a susceptibility gene for psoriasis and psoriatic arthritis.
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Acknowledgements
This work was supported by a grant from the General Program of National Natural Science Foundation of China (81000692, 30971644). We thank for assistance from YF. Zou and Y Fan (Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University). We received the kind help of Dr. Graell and Dr. Yazdanyar who have given us detailed explanation of their research.
This work was supported by a grant from the General Program of National Natural Science Foundation of China (81000692, 30971644).
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Zhu, K., Yin, X., Tang, X. et al. Meta-analysis of NOD2/CARD15 polymorphisms with psoriasis and psoriatic arthritis. Rheumatol Int 32, 1893–1900 (2012). https://doi.org/10.1007/s00296-011-1813-2
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DOI: https://doi.org/10.1007/s00296-011-1813-2