Skip to main content

Advertisement

SpringerLink
Log in

Fatal rhabdomyolysis in systemic lupus erythematosus

  • Short Communication
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The authors describe herein the sixth lupus case that evolved with rhabdomyolysis. A 36-year-old woman with systemic lupus erythematosus was admitted to our hospital with malaise, myalgia, dysphagia, fever, preserved muscle strength, leukocytosis (15,600 cells), and increased creatine kinase of 1,358 IU/L that reached 75,000 IU/L in few days. She denied the use of myotoxic drugs and alcohol. Urine 1 showed false positive for hemoglobinuria (myoglobin) without erythrocytes in the sediment, confirming the diagnosis of rhabdomyolysis. Secondary causes were excluded. She was treated with hyperhydration and alkalinization of urine. Despite treatment, the patient developed pulmonary congestion and she died. The authors also review in this article rhabdomyolysis in patients with systemic lupus erythematosus.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Khan FY (2009) Rhabdomyolysis: a review of the literature. Neth J Med 67:272–283

    PubMed  CAS  Google Scholar 

  2. Bagley WH, Yang H, Shah KH (2007) Rhabdomyolysis. Intern Emerg Med 2:210–218

    Article  PubMed  CAS  Google Scholar 

  3. Polderman KH (2004) Acute renal failure and rhabdomyolysis. Int J Artif Organs 27:1030–1033

    PubMed  CAS  Google Scholar 

  4. Huerta-Alardín AL, Varon J, Marik PE (2005) Bench-to-bedside review: rhabdomyolysis–an overview for clinicians. Crit Care 9:158–169

    Article  PubMed  Google Scholar 

  5. Chatzizisis YS, Misirli G, HAtzitolios AI, Giannoglou GD (2008) The syndrome of rhabdomyolysis: complilcations and treatment. Eur J Intern Med 19:568–574

    Article  PubMed  Google Scholar 

  6. Joshi D, Kumar N, Raj A (2009) Dermatomyositis presenting with rhabdomyolysis and acute renal failure: na uncommon manifestation. Ann Indian Acad Neurol 12:45–47

    PubMed  Google Scholar 

  7. Creel N, Worth V (2005) Rhabdomyolysis associated with quinacrine therapy in a patient with chronic cutaneous lupus erythematosus. J Drugs Dermatol 4:225–227

    PubMed  Google Scholar 

  8. Blaauw AA, Tobé TJ, Derksen RW, Bijlsma JW (2000) A patient with systemic lupus erythematosus and Salmonella enteritidis bacteraemia complicated by rhabdomyolysis and acute cholecystitis. Rheumatology (Oxford) 39:110–112

    Article  CAS  Google Scholar 

  9. Menon S, Round JM, Isenberg DA (1994) Rhabdomyolysis in a patient with discoid lupus erythematosus. J Rheumatol 21:1967–1969

    PubMed  CAS  Google Scholar 

  10. Schubert J, Manschwetus H, Walter GF, Zeidler H, Schmidt RE (1991) Systemic lupus erythematosus (SLE) with panniculitis and rhabdomyolysis. Immun Infekt 19:58–59

    PubMed  CAS  Google Scholar 

  11. Maltz HC, Balog DL, Cheigh JS (1999) Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine. Ann Pharmacother 33:1176–1179

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

JF Carvalho received grants from Federico Foundation and CNPq (300665/2009-1).

Author information

Authors and Affiliations

  1. Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, 3º andar, sala 3190, Cerqueira César, São Paulo, SP, 01246-903, Brazil

    Jozélio Freire de Carvalho & Eloisa Bonfa

  2. Rheumatology Service, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF, Brazil

    Licia Maria Henrique da Mota

Authors
  1. Jozélio Freire de Carvalho
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Licia Maria Henrique da Mota
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eloisa Bonfa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jozélio Freire de Carvalho.

Rights and permissions

Reprints and permissions

About this article

Cite this article

de Carvalho, J.F., da Mota, L.M.H. & Bonfa, E. Fatal rhabdomyolysis in systemic lupus erythematosus. Rheumatol Int 31, 1243–1245 (2011). https://doi.org/10.1007/s00296-010-1674-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-010-1674-0

Keywords

Search

Navigation