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MicroRNA array analysis of microRNAs related to systemic scleroderma

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An Erratum to this article was published on 15 October 2011

Abstract

MicroRNAs are short, 18- to 25-nt sequences of noncoding, single-stranded RNA that function as regulatory molecules and participate in a series of vital processes including early development, cell proliferation, cell differentiation, apoptosis, substance metabolism and the pathogenesis of human diseases. This study compared the microRNA profiles of patients with systemic scleroderma (SSc) and healthy control individuals to investigate the pathogenesis of SSc. Skin tissue was isolated from three patients with SSc and three healthy controls. miRNA microarray chip analysis identified 24 miRNAs that were differentially expressed in patients with SSc and 6 microRNAs that may be correlated with the pathogenesis of SSc. The results of the microarray analysis were confirmed using real-time PCR. This work suggests that miRNAs may be potential diagnosis biomarkers and are likely to be involved in the pathogenesis of SSc.

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Acknowledgments

The authors thank the patients and healthy volunteers who participated in this study and the workers of Dermatology and Venereology Department, Beijing Military Command General Hospital of PLA, who helped with this research.

Conflict of interest

The authors have declared that no conflict of interest exists.

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Authors and Affiliations

  1. Department of Dermatology and Venerology, Beijing Military Command General Hospital of PLA, Beijing, 100125, China

    Haitao Li, Rongya Yang, Xin Fan, Tingmin Gu, Zhili Zhao, Dongqing Chang, Wenling Wang & Congmin Wang

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  1. Haitao Li
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  2. Rongya Yang
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  3. Xin Fan
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  4. Tingmin Gu
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  5. Zhili Zhao
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  7. Wenling Wang
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  8. Congmin Wang
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Corresponding author

Correspondence to Rongya Yang.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s00296-011-2165-7.

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Li, H., Yang, R., Fan, X. et al. MicroRNA array analysis of microRNAs related to systemic scleroderma. Rheumatol Int 32, 307–313 (2012). https://doi.org/10.1007/s00296-010-1615-y

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  • DOI: https://doi.org/10.1007/s00296-010-1615-y

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