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Long-term remission after successful pregnancy in autologous peripheral blood stem cell transplanted system lupus erythematosus patients

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Abstract

Pregnancies in systemic lupus erythematosus (SLE) patients are high risk to both mother and fetus because of increased rates of complications. During the past years, we have treated many cases of SLE patients using autologous peripheral blood stem cell transplantation with good outcome after pregnancy. The rate of maternal hypertension and lupus nephritis was greatly reduced in autologous peripheral blood stem cell transplanted group (n = 11) when compared to non-transplant group (n = 39) (P < 0.05). In addition, the outcome of lupus flare activity of the mother after delivery is significantly better in transplanted group than that in non-transplanted group (P < 0.05). Here, we describe two typical cases of long duration (>6 years) of remission after successful pregnancy in refractory SLE patients post-autologous peripheral blood stem cell transplantation. Our report demonstrated that peripheral blood stem cell transplantation is safe and effective, thereby could be recommended as prior strategy in refractory SLE patients, especially for those women of child-bearing age who plan for pregnancy.

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References

  1. Clowse M, Jamison M, Myers E et al (2008) A national study of the complications of lupus pregnancy. Am J Obstet Gynecol 199:127.e1–127.e6

    Article  Google Scholar 

  2. Molad Y (2006) Systemic lupus erythematosus and pregnancy. Curr Opin Obstet Gynecol 18:613–617

    Article  PubMed  Google Scholar 

  3. Wagner SJ, Craici I, Reed D et al (2009) Maternal and fetal outcomes in pregnant patients with active lupus nephritis. Lupus 18:342–347

    Article  PubMed  CAS  Google Scholar 

  4. Burt RK, Traynor AE (2003) Hematopoietic stem cell transplantation for systemic lupus erythematosus. Arthritis Res Ther 5:207–209

    Article  PubMed  Google Scholar 

  5. Marmont AM (1998) Stem cell transplantation for severe autoimmune diseases: progress and problems. Haematologica 83:733–743

    PubMed  CAS  Google Scholar 

  6. Ikehara S (1998) Bone marrow transplantation for autoimmune diseases. Acta Haematol 99:116–132

    Article  PubMed  CAS  Google Scholar 

  7. Molad Y, Borkowski T, Monselise A et al (2005) Maternal and fetal outcome of lupus pregnancy: a prospective study of 29 pregnancies. Lupus 14:145–151

    Article  PubMed  CAS  Google Scholar 

  8. Marmont AM, van Lint MT, Gualandi F et al (1997) Autologous marrow stem cell transplantation for severe systemic lupus erythematosus of long duration. Lupus 6:545–548

    Article  PubMed  CAS  Google Scholar 

  9. Burt RK, Traynor A, Ramsey-Goldman R (1997) Hematopoietic stem cell transplantation for systemic lupus erythematosus. N Engl J Med 337:1777–1778

    Article  PubMed  CAS  Google Scholar 

  10. Traynor AE, Schroeder J, Rosa RM et al (2000) Treatment of severe systemic lupus erythematosus with high-dose of chemotherapy and haemopoietic stem-cell transplantation: a phase I study. Lancet 356:701–707

    Article  PubMed  CAS  Google Scholar 

  11. Traynor A, Burt RK (1999) Haematopoietic stem cell transplantation for active systemic lupus erythematosus. Rheumatology 8:767–772

    Article  Google Scholar 

  12. Burt RK, Slavin S, Burns Wh et al (2002) Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure? Blood 99:870–887

    Article  Google Scholar 

  13. Traynor A, Barr WG, Rosa RM et al (2002) Hametopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients. Arthritis Rheum 46:2917–2923

    Article  PubMed  Google Scholar 

  14. Theophilopoulos AN (1995) The basis of autoimmunity: part II. Genetic predisposition. Immunol Today 16:150–159

    Article  Google Scholar 

  15. Marmont AM (1994) Immune ablation followed by a allogeneic or autologous bone marrow transplantation: a new treatment for severe autoimmune diseases? Stem Cells 12:125–135

    Article  PubMed  CAS  Google Scholar 

  16. Buyon JP, Petri MA, Kim MY et al (2005) The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trail. Ann Intern Med 142:953–962

    PubMed  CAS  Google Scholar 

  17. Pisoni CN, D’Cruz DP (2008) The safety of mycophenolate mofetil in pregnancy. Expert Opin Drug Saf 7:219–222

    Article  PubMed  CAS  Google Scholar 

  18. Thompson A, Han VKM, Yang K (2002) Spatial and temporal patterns of expression of 11b-hydroxysteroid dehydrogenase types 1 and 2 messenger RNA and glucocorticoid receptor protein in the murine placenta and uterus during late pregnancy. Biol Reprod 67:1708–1718

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hematology, Hebei Medical University Third Hospital, Ziqiang Road 139, Shijiazhuang, 050051, Hebei, China

    Jianbo Meng

  2. Department of Rheumatism, Hebei Medical University Third Hospital, Ziqiang Road 139, Shijiazhuang, 050051, Hebei, China

    Jinkai Wang

  3. Intergrated Chinese Traditional and Western Medical College, Hebei Medical University Third Hospital, Ziqiang Road 139, Shijiazhuang, 050051, Hebei, China

    Wenjie Liang

  4. Department of Gynecology and Obstetrics, Hebei Medical University Third Hospital, Ziqiang Road 139, Shijiazhuang, 050051, Hebei, China

    Shan Qin

  5. Department of Intensive Care Unit, Hebei Medical University Third Hospital, Ziqiang Road 139, Shijiazhuang, 050051, Hebei, China

    Chuntao Wu

Authors
  1. Jianbo Meng
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  2. Jinkai Wang
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  3. Wenjie Liang
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  4. Shan Qin
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  5. Chuntao Wu
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Corresponding authors

Correspondence to Jianbo Meng or Chuntao Wu.

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Meng, J., Wang, J., Liang, W. et al. Long-term remission after successful pregnancy in autologous peripheral blood stem cell transplanted system lupus erythematosus patients. Rheumatol Int 31, 691–694 (2011). https://doi.org/10.1007/s00296-010-1588-x

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  • DOI: https://doi.org/10.1007/s00296-010-1588-x

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