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Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system

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Abstract

To apply the Osteoarthritis Research Society International (OARSI) assessment system to an osteoarthritis model, 44 Wistar rats were randomized into treadmill-running exercise or control group. At 6, 8, and 10 weeks, medial knee joints were histopathologically evaluated, and aggrecan neoepitope and TUNEL staining were performed. Cartilage changes in exercise group were histopathologically and histochemically compatible with early OA. Total modified Mankin system (MMS) scores were significantly higher at all time points (each P ≤ 0.01) in exercise than in control group. However, only tibial OARSI scores of runners were higher at 10 weeks (P < 0.05), although OARSI scores were found to be significantly correlated with MMS scores. Both total MMS (Spearman’s coefficient ρ = 0.786) and OARSI scores (ρ = 0.443 for femoral; ρ = 0.604 for tibial) were significantly associated with the exercise duration. In conclusion, the OARSI system may not be sensitive to early OA changes induced by treadmill exercise.

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Acknowledgments

This work was supported by a grant of the Korea Heath 21 R&D project, Ministry of Health & Welfare, Republic of Korea (HMP-00-C11-08-0007), and partially by the Basic Research Program of the Korean Science and Engineering Foundation, Korea (2008-05669) and by a grant no 800-20090008 from the Seoul National University Hospital Research Fund & 800-20090008 from the Seoul National University college of Medicine.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Internal Medicine, Clinical Research Institute, Seoul National University College of Medicine, 28 Yongun-dong, Chongno-gu, Seoul, 110-744, Korea

    Yun Jong Lee, Ji Ah Park, Kwang Yong Kim, Eun Young Lee, Eun Bong Lee & Yeong Wook Song

  2. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, Jeonbuk, 570-749, Korea

    Sei Hoon Yang

  3. Department of Pathology, Clinical Research Institute, Seoul National University College of Medicine, 28 Yongun-dong, Chongno-gu, Seoul, 110-744, Korea

    Byoung Kwon Kim & Jeong-Wook Seo

  4. Department of Anesthesiology and Intensive Care Medicine, Medical School Hannover, Hannover, Germany

    Frank Echtermeyer

  5. Division of Molecular Medicine of Musculoskeletal Tissue, Department of Orthopedics, University Hospital Munster, Domagkstr. 3, 48149, Muenster, Germany

    Thomas Pap

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  1. Yun Jong Lee
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  2. Ji Ah Park
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Corresponding author

Correspondence to Yeong Wook Song.

Additional information

Y.J. Lee and J.A. Park contributed equally to this work.

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Lee, Y.J., Park, J.A., Yang, S.H. et al. Evaluation of osteoarthritis induced by treadmill-running exercise using the modified Mankin and the new OARSI assessment system. Rheumatol Int 31, 1571–1576 (2011). https://doi.org/10.1007/s00296-010-1520-4

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  • DOI: https://doi.org/10.1007/s00296-010-1520-4

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