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Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis

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Abstract

The objective of this study was to investigate adiponectin levels in both plasma and synovial fluid of female patients with knee osteoarthritis (OA) and to analyze the correlation between adiponectin and degradation markers of cartilage matrix in synovial fluid. Thirty female patients with knee OA were enrolled in this study. Levels of adiponectin and degradation markers of cartilage matrix were measured using enzyme-linked immunosorbent assay. Adiponectin level in synovial fluid was significantly lower with respect to paired plasma level (0.93 ± 0.64 vs. 7.50 ± 3.29 μg/ml, P < 0.001). Correlation analysis showed that synovial fluid adiponectin significantly correlated with degradation markers of aggrecan, AGG1 (r = 0.441, P = 0.015) and AGG2 (r = 0.445, P = 0.014), but not significantly correlated with degradation marker of collagen II, CTX-II. These findings suggest that adiponectin might involve in the regulation of the degradation of cartilage matrix in OA.

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Acknowledgments

The authors would like to thank Dr. Jin Jin, Jin Lin, and Xisheng Wen for their help in sample collections and Linxin Xu for technical assistance.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Dongsheng Hao, Ming Li, Zhihong Wu, Yuanhui Duan, Deling Li & Guixing Qiu

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  1. Dongsheng Hao
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  2. Ming Li
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  3. Zhihong Wu
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  4. Yuanhui Duan
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  5. Deling Li
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  6. Guixing Qiu
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Correspondence to Guixing Qiu.

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Hao, D., Li, M., Wu, Z. et al. Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis. Rheumatol Int 31, 1433–1437 (2011). https://doi.org/10.1007/s00296-010-1516-0

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  • DOI: https://doi.org/10.1007/s00296-010-1516-0

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