Abstract
We report the case of a 35-years-old renal transplant patient known to have familial Mediterranean fever with serum amyloid A (SAA)-amyloidosis, who presented with his second episode of bilateral pneumonia. As antimicrobials failed to control the first episode of pneumonia and all studies done were non-contributory, we attributed the condition to the highly active Mediterranean fever presumably resistant to colchicine and treated the patient with the interleukin-1 receptor antagonist anakinra: the patient substantially improved by clinical symptoms, chemistry and radiological evidence within no more than 2 days and was discharged in good health after 4 days.
References
Lachmann HJ, Sengul B, Yavuzsen TU (2006) Clinical and subclinical inflammation in patients with familial Mediterranean fever and in heterozygous carriers of MEFV mutations. Rheumatology 45:746–750
Onen F (2006) Familial Mediterranean fever. Rheumatol Int 26:489–496
The International FMF Consortium (1997) Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. Cell 90:797–807
The French FMF Consortium (1997) A candidate gene for familial Mediterranean fever. Nat General 17:25–31
Livneh A, Langevitz P (2000) Diagnostic and treatment concerns in familial Mediterranean fever. Baillieres Best Pract Res Clin Rheumatol 14:477–498
Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL (2008) The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kB through ist N-terminal fragment. Blood 112:1794–1803
Ilfeld DN, Mazar A, Garty M, Fink G, Spitzer S, Pecht M, Netzer L, Trainin N, Kuperman O (1986) Effect of oral colchicine on T cell subsets, monocytes and concanavalin A-induced suppressor cell function in asthmatic patients. Clin Allergy 16:407–416
Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL (2006) The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci USA 103:9982–9987
Kineret® (anakinra) (2008) Prescribing information, medical information connection US, 2008 Amgen
Bresnihan B (2001) The safety and efficacy of interleukin-1 receptor antagonist in the treatment of rheumatoid arthritis. Semin Arthritis Rheum 30:17–20
Roldan R, Ruiz AM, Miranda MD, Collantes E (2008) Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. Joint Bone Spine 75:504–505
Kuijk LM, Govers AM, Frenkel J, Hofhuis WJ (2007) Effective treatment of a colchicine-resistant familial Mediterranean fever patient with anakinra. Ann Rheum Dis 66:1545
Calligaris L, Marchetti F, Tommasini A, Ventura A (2008) The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever. Eur J Pediatr 167:695–696
Gattringer R, Lagler H, Gattringer KB, Knapp S, Burgmann H, Winkler S, Graninger W, Thalhammer F (2007) Anakinra in two adolescent female patients suffering from colchicine-resistant familial Mediterranean fever: effective but risky. Eur J Clin Invest 37:912–914
Moser C, Pohl G, Haslinger I, Knapp S, Rowczenio D, Russel T, Lachmann HJ, Lang U, Kovarik J (2009) Successful treatment of Familial Mediterranean fever with Anakinra and outcome after renal transplantation. Nephrol Dial Transplant 24:676–678
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Hennig, S., Bayegan, K., Uffmann, M. et al. Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra—case report and review. Rheumatol Int 32, 1801–1804 (2012). https://doi.org/10.1007/s00296-010-1429-y
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DOI: https://doi.org/10.1007/s00296-010-1429-y