Abstract
The aim of this study was to summarize results on the association of tumor necrosis factor-α (TNF-α) promoter –308A/G polymorphism with systemic lupus erythematosus (SLE) susceptibility in Asian populations by using the meta-analysis. We searched all the publications about the association between TNF-α promoter –308A/G polymorphism and SLE in Asian populations from PubMed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Meta-analysis was performed for genotypes AA versus GG, GA versus GG, AA versus GG + GA, GA + AA versus GG, and A allele versus G allele in a fixed/random effect model. A total of 12 studies (1017 cases and 1086 controls) were included in the current meta-analysis (Chinese, Japanese, and Thai). When all groups were pooled, a significant association of A allele and increased SLE risk was found (OR = 1.44, 95%CI = 1.04–2.01, P = 0.03). When analyses were restricted to more ethnically homogeneous populations, similar result was found in Chinese population (OR = 1.59, 95%CI = 1.12–2.26, P = 0.009). But the association between TNF-α promoter –308 polymorphism and SLE was not observed when examining the contrast of G/A + A/A versus G/G, A/A versus A/G + G/G, A/A versus G/G, and G/A versus G/G. This meta-analysis demonstrates the association between TNF-α promoter –308A/G polymorphism and SLE in Asian populations, especially in Chinese population.
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Acknowledgments
We thank all the people who give the help for this study. Especially, we have got the kind help from Dr. Tatsuya Atsumi, he sent us his original paper by express company. This work was supported by grants from the National Natural Science Foundation of China (30830089).
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The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.
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Zou, YF., Feng, XL., Tao, JH. et al. Meta-analysis of TNF-α promoter –308A/G polymorphism and SLE susceptibility in Asian populations. Rheumatol Int 31, 1055–1064 (2011). https://doi.org/10.1007/s00296-010-1392-7
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DOI: https://doi.org/10.1007/s00296-010-1392-7