Abstract
The objective of this study is to establish whether there is an association between the presence of FCGR3A V(176) polymorphism with SLE or its manifestations. We included 94 patients according to the 1982 ACR criteria as well as 98 controls matched by age and gender. The 11 ACR diagnostic criteria were analyzed on the clinical files. The polymorphism FCGR3A V(176) was determined by direct sequencing. There was not an association between the polymorphism FCGR3A V(176) with SLE or its main manifestations. The allelic frequency for F(176) was: 0.80 and 0.72 in cases and controls, respectively (P = 0.09, IC95%: 0.42–1.07); and the genotypic frequency in the group of cases was: 0.65 for homozygotes F(176)/F(176), 0.30 for heterozygotes and 0.05 for the homozygotes V(176)/V(176), while for the control group it was 0.53, 0.39 and 0.08, respectively. The polymorphism FCGR3A V(176) is not associated with SLE or any of its manifestations in patients with SLE from the West of Mexico.
Similar content being viewed by others
References
Krishnan S, Chowdhury B, Tsokos GC (2006) Autoimmunity in systemic lupus erythematosus, integration genes and biology. Semin Immunol 18:230–243
Dijstelbloem HM, Bijl M, Fijnheer R et al (2000) Fcgamma receptor polymorphisms in systemic lupus erythematosus. Arthritis Rheum 43:2793–2800
Kyogoku C, Dijstelbloem HM, Tsuchiya N et al (2002) Fcγ receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus. Arthritis Rheum 46:1242–1254
Karassa FB, Trikalinos TA, Ioannidis JP (2003) The Fc gamma RIIIA-F158 allele is a risk factor for the development of lupus nephritis: a meta-analysis investigators and. Kidney Int 63:1475–1482
Zuñiga R, Ng Sonia, Peterson MGE et al (2001) Low-binding alleles of Fcγ receptor types IIA and IIIA are inherited independently and are associated with systemic lupus erythematosus in hispanic patients. Arthritis Rheum 44:361–367
Seligman VA, Suarez C, Lum R et al (2001) The Fcγ receptor IIIA-158F allele is a major risk factor for the development of lupus nephritis among caucasians but not non-caucasians. Arthritis Rheum 44:618–625
Magnusson V, Johanneson B, Lima G et al (2004) Both risk alleles for Fc gammaRIIA and Fc gammaRIIIA are susceptibility factors for SLE: a unifying hypothesis. Genes Immun 5:130–137
Manger K, Repp R, Jansen M et al (2002) Receptor IIa, IIIa, and IIIb polymorphisms in German patients with systemic lupus erythematosus: association with clinical symptoms. Ann Rheum Dis 61:786–792
Edberg JC, Langefeld CD, Wu J et al (2002) Genetic linkage association of Fcγ receptor RIIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum 46:2132–2139
Rubi-Castellanos R, Martínez-Cortés G, Francisco Muñoz-Valle J, et al (2009) Pre-Hispanic Mesoamerican demography approximates the present-day ancestry of Mestizos throughout the territory of Mexico. Am J Phys Anthropol
Tan PL, Borman GB, Wigley RD (1981) Testing clinical criteria for systemic lupus erythematosus in other connective tissue disorders. Rheumatol Int 1:147–149
Miller SA, Dykes DD, Polesky HP (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acid Res 16:1215
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Brambila-Tapia, A.J.L., Gámez-Nava, J.I., González-López, L. et al. FCGR3A V(176) polymorphism for systemic lupus erythematosus susceptibility in Mexican population. Rheumatol Int 31, 1065–1068 (2011). https://doi.org/10.1007/s00296-010-1391-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-010-1391-8