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Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study

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Abstract

The objective of this study is to evaluate the association between radiographic hand osteoarthritis and serum level of osteocalcin. The study population comprised Chuvashians (285 males, age 47.38 ± 16.79; 265 females, age 48.55 ± 15.94 years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K–L), joint space narrowing (JSN) and osteophytes (OS) scores. Plasma-intact osteocalcin was measured in 550 individuals by immunoradiometric assay using ELSA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions. 51.64% of studied individuals had at least one finger joint affected at K–L ≥2 level. JSN at the level ≥2 was found in 9.82% and OS ≥2 was found in 35.09% of the studied individuals. Osteocalcin showed a modest, but statistically significant, association with the number of affected joints according the K–L scale (beta = 0.082, p = 0.015), JSN scale (beta = 0.097, p = 0.025) and OS scale (beta = 0.078, p = 0.029). No significant association was found between the presence of at least one affected joint (K–L ≥ 2 or OS ≥ 2) and serum level of osteocalcin. Presence of at least one joint with space narrowing ≥2 was significantly associated with serum level of osteocalcin (beta = 0.052, p = 0.023). In this cross-sectional population-based study, we found that serum level of osteocalcin is positively associated with severity of hand OA, measured by K–L, JSN and OS scales.

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Authors and Affiliations

  1. Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, 84105, Beer Sheva, Israel

    Leonid Kalichman

  2. Research Unit, Human Population Biology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Eugene Kobyliansky

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  1. Leonid Kalichman
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  2. Eugene Kobyliansky
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Correspondence to Leonid Kalichman.

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Kalichman, L., Kobyliansky, E. Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study. Rheumatol Int 30, 1131–1135 (2010). https://doi.org/10.1007/s00296-010-1372-y

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  • DOI: https://doi.org/10.1007/s00296-010-1372-y

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