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Intra-articular corticosteroid therapy for juvenile idiopathic arthritis: report of an experiential cohort and literature review

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Abstract

The objective of the study to review an experiential cohort of patients receiving IACS and review the associated literature. Review of 121 IACS in 61 patients with JIA. At 3-month intervals, injected joints were evaluated for swelling and range of motion, and the patient and parent were questioned regarding associated pain and morning stiffness. Data were analyzed by log-rank analysis according to injected corticosteroid preparation and its dosage. Adverse events were also recorded. A thorough literature search was done for the literature review. Mean duration of response was 12.5 months (52% of joints in remission at 1 year, 20% after 2 years, and 7% after 3 years). Response was longer with at least 1 mg/kg of corticosteroid, with the longest responses seen with triamcinolone hexacetonide (THA) > triamcinolone acetonide > methylprednisolone. Adverse events were cutaneous atrophy at three injections sites (2.5%), and transient Cushingoid habitus and increased appetite in two patients (3%). Review of the literature generated similar responses to those included herein. Thus, there have been several recommendations for IACS to be a major JIA treatment, and surveys now demonstrate a high level of usage by pediatric rheumatologists. In conclusion the use of IACS in JIA substantiated. THA at a dose of 1–1.5 mg/kg is ideal.

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Authors and Affiliations

  1. Clinical Research, Shire Human Genetic Therapies, 700 Main Street, Cambridge, MA, 02139, USA

    Bradley J. Bloom

  2. Hasbro Children’s Hospital, Providence, RI, USA

    Bradley J. Bloom

  3. Ambulatory Pediatrics, Hasbro Children’s Hospital, Brown University Medical School, Providence, RI, USA

    Anthony J. Alario

  4. Division of Pediatric Rheumatology, Floating Hospital for Children, Tufts University Medical School, Boston, MA, USA

    Laurie C. Miller

Authors
  1. Bradley J. Bloom
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  2. Anthony J. Alario
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  3. Laurie C. Miller
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Correspondence to Bradley J. Bloom.

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Bloom, B.J., Alario, A.J. & Miller, L.C. Intra-articular corticosteroid therapy for juvenile idiopathic arthritis: report of an experiential cohort and literature review. Rheumatol Int 31, 749–756 (2011). https://doi.org/10.1007/s00296-010-1365-x

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  • DOI: https://doi.org/10.1007/s00296-010-1365-x

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