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Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1

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Abstract

Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in many regions of the world, including Brazil, and has been associated to several immunological manifestations such as arthritis, uveitis, dermatitis and Sjögren’s syndrome. This study was intended to evaluate the frequency of autoantibodies in patients infected with HTLV-1 and manifesting keratoconjunctivitis sicca (KCS). HTLV-1 patients with KCS, enrolled in a reference ambulatory of the city of Salvador, were tested for autoantibodies such as antinuclear antibodies, rheumatoid factor, anti-SSA/Ro and anti-SSB/La. Two comparison groups were also included: (a) HTLV-1 patients without KCS and (b) seronegative patients with KCS. Correlation of proviral load (PVL) in HTLV-1 patients with presence or absence of KCS was also assessed. No autoantibodies were detected in HTLV-1 patients with KCS. The PVL of HTLV-1 patients was higher in patients with KCS without other clinical manifestations customarily associated to HTLV-1. In conclusion, in this study, no changes were observed in humoral immunity concerning production of certain autoantibodies in HTLV-1-infected patients with KCS, which suggests that other mechanisms may be involved in the pathogenesis of this manifestation. Additionally, PVL may be a marker of KCS development in these patients.

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Acknowledgments

The authors thank Professor Fernanda Grassi for the excellent suggestions provided during the manuscript preparation. MS received a scholarship from CNPq.

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Authors and Affiliations

  1. Instituto Brasileiro de Oftalmologia e Prevenção à Cegueira [Brazilian Institute for Ophthalmology and Prevention of Blindness], Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil

    Ana Karina Ferraz-Chaoui

  2. Immunology Research Laboratory, Department of the UFBA, Clinical and Toxicological Analysis, Faculty of Pharmacy, UFBA, Salvador, Brazil

    Ajax Mercês Atta & Maria Luiza Sousa Atta

  3. HTLV/Viral Hepatitis Integrative Center of EBMSP/FBDC/FIOCRUZ, EBMSP, Salvador, Brazil

    Bernardo Galvão-Castro

  4. Serviço de Reumatologia do HSI, EBMSP, Praça Conselheiro Almeida Couto, 500, Nazaré, CEP 40000-000, Salvador, Bahia, Brazil

    Mittermayer B. Santiago

Authors
  1. Ana Karina Ferraz-Chaoui
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  2. Ajax Mercês Atta
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  3. Maria Luiza Sousa Atta
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  4. Bernardo Galvão-Castro
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  5. Mittermayer B. Santiago
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Correspondence to Mittermayer B. Santiago.

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Ferraz-Chaoui, A.K., Atta, A.M., Atta, M.L.S. et al. Study of autoantibodies in patients with keratoconjunctivitis sicca infected by the human T cell lymphotropic virus type 1. Rheumatol Int 30, 775–778 (2010). https://doi.org/10.1007/s00296-009-1066-5

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  • DOI: https://doi.org/10.1007/s00296-009-1066-5

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