Abstract
Development of uroepithelial tumors after cyclophosphamide and azathioprine therapy in Wegener’s granulomatosis (WG) have been reported in the literature but renal cell carcinoma (RCC), rarely. RCC associated with WG has been previously reported in a few cases. Most of them have simultaneous diseases. Here, we report a case, which developed RCC 8 years after initiation of WG. Long-term immunosuppressive treatment is a risk factor for the development of malignancies; it should be suggested that RCC in our patient might be due to immunosuppressive therapy.
References
Hoffman GS, Kerr GS, Leavitt RY et al (1992) Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488–498
Reynolds RD, Simerville JJ, O’Hara DD et al (1969) Hemorrhagic cystitis due to cyclophosphamide. J Urol 101:45
Westman KWA, Bygren PG, Olsson H et al (1998) Relaps rate, renal survival and cancer morbiditiy in patients with Wegener’s granulomatosis or microscopic polyangiitis with renal involvement. J Am Soc Nephrol May 9(5):842–852
Penn I (1978) Malignancies associated with immunosuppressive or cytotoxic therapy. Surgery 83:492–502
Odeh M (1996) Renal cell carcinoma associated with cyclophosphamide therapy for wegener’s granulomatosis. Scand J Rheumatol 25:391–393. doi:10.3109/03009749609065652
Jayne D, Rasmussen N, Andrassy K et al (2003) A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 349:36–44. doi:10.1056/NEJMoa020286
Yakupoglu YK, Buell JF, Woodle S, Kahan BD (2006) Individualization of Immunosuppressive Therapy. III. Sirolimus associated with a reduced incidence of malignancy. Transplant Proc 38(2):358–361
Satsangi J, Marshall J, Roskell D, Jewell D (1996) Ulcerative colitis complicated by renal cell carcinoma: a series of three patients. Gut January 38(1):148–150
Edgar JDM, Rooney DP, Mc Namee P, Mc Neill TA (1993) An association between ANCA positive renal disease and malignancy. Clin Nephrol 40(18):22–25
Lloyd M, Verteuil J, Andrews PA (2002) Renal vasculitis associated with renal cell carcinoma. J R Soc Med 95:305–306. doi:10.1258/jrsm.95.6.305
Villa-Forte A, Hoffman GS (1999) Wegener’s granulomatosis presenting with a renal mass. J Rheum 26(2):457–458
Tatsis E, Reinhold-Keller E, Steindorf K et al (1999) Wegener’s granulomatosis associated with renal cell carcinoma. Arthritis Rheum 42(4):751–756. doi:10.1002/1529-0131(199904)42:4<751::AID-ANR19>3.0.CO;2-D
Stone JF, Holbrook JT, Marriott MA et al (2006) Solid malignancies among patients in the Wegener’ s Granulomatosis Etanercept trial. Arthritis Rheum 54(5):1608–1618. doi:10.1002/art.21869
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Deger, S.M., Mutluay, R., Ebinc, F.A. et al. Renal cell carcinoma associated immunosuppressive therapy: a case report with Wegener’s granulomatosis. Rheumatol Int 30, 119–121 (2009). https://doi.org/10.1007/s00296-009-0911-x
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DOI: https://doi.org/10.1007/s00296-009-0911-x