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Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis

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Abstract

This study was designed to investigate the serum and synovial fluid leptin levels, and inflammatory markers in rheumatoid arthritis (RA) patients. Serum and synovial fluid leptin levels were significantly higher (P > 0.05) in RA patients than control group; RA patients with moderate disease activity (DAS < 2.7) having significantly higher leptin levels (P > 0.05) than those with low disease activity (DAS < 2.7). Leukocytes and erythrocyte sedimentation rate (ESR) were found to be significantly higher in moderate disease activity RA group compared to low activity group (P > 0.05, P < 0.001, respectively). Serum leptin level is found to be independent of age and inflammatory markers. ESR is positively correlated with DAS activity and CRP values. Our finding of no correlation between leptin and BMI shows that regulation of leptinemia is complex, and leptin levels cannot be used to assess RA activity.

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References

  1. Palmer G, Gabay C (2003) A role for leptin in rheumatic diseases? Ann Rheum Dis 62(10):913–915. doi:10.1136/ard.62.10.913

    Article  PubMed  CAS  Google Scholar 

  2. Otero M, Lago R, Lago F et al (2005) Leptin, from fat to inflammation: old questions and new insights. FEBS Lett 579(2):295–301. doi:10.1016/j.febslet.2004.11.024

    Article  PubMed  CAS  Google Scholar 

  3. Auwerx J, Staels B (1998) Leptin. Lancet 351(9104):737–742. doi:10.1016/S0140-6736(97)06348-4

    Article  PubMed  CAS  Google Scholar 

  4. Faggioni R, Feingold KR, Grunfeld C (2001) Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15(14):2565–2571. doi:10.1096/fj.01-0431rev

    Article  PubMed  CAS  Google Scholar 

  5. Otero M, Lago R, Gomez R et al (2006) Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford) 45(8):944–950. doi:10.1093/rheumatology/kel157

    Article  CAS  Google Scholar 

  6. Loffreda S, Yang SQ, Lin HZ et al (1998) Leptin regulates proinflammatory immune responses. FASEB J 12(1):57–65

    PubMed  CAS  Google Scholar 

  7. Busso N, So A, Chobaz-Péclat V et al (2002) Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis. J Immunol 168(2):875–882

    PubMed  CAS  Google Scholar 

  8. Arnett FC, Edworthy SM, Bloch DA (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324. doi:10.1002/art.1780310302

    Article  PubMed  CAS  Google Scholar 

  9. van der Heijde DM, van’t Hof M, van Riel PL, van de Putte LB (1993) Development of a disease activity score based on judgment in clinical practice by rheumatologists. J Rheumatol 20(3):579–581

    PubMed  Google Scholar 

  10. Lee SW, Park MC, Park YB, Lee SK (2007) Measurement of the serum leptin level could assist disease activity monitoring in rheumatoid arthritis. Rheumatol Int 27(6):537–540. doi:10.1007/s00296-006-0253-x

    Article  PubMed  CAS  Google Scholar 

  11. Otero M, Lago R, Gomez R et al (2006) Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 65(9):1198–1201. doi:10.1136/ard.2005.046540

    Article  PubMed  CAS  Google Scholar 

  12. Bokarewa M, Bokarew D, Hultgren O, Tarkowski A (2003) Leptin consumption in the inflamed joints of patients with rheumatoid arthritis. Ann Rheum Dis 62(10):952–956. doi:10.1136/ard.62.10.952

    Article  PubMed  CAS  Google Scholar 

  13. Wisołwska M, Rok M, Jaszczyk B, Stepień K, Cicha M (2007) Serum leptin in rheumatoid arthritis. Rheumatol Int 27(10):947–954. doi:10.1007/s00296-007-0335-4

    Google Scholar 

  14. Gunaydin R, Kaya T, Atay A, Olmez N, Hur A, Koseoglu M (2006) Serum leptin levels in rheumatoid arthritis and relationship with disease activity. South Med J 99(10):1078–1083

    PubMed  Google Scholar 

  15. Anders HJ, Rihl M, Heufelder A, Loch O, Schattenkirchner M (1999) Leptin serum levels are not correlated with disease activity in patients with rheumatoid arthritis. Metabolism 48(6):745–748. doi:10.1016/S0026-0495(99)90174-9

    Article  PubMed  CAS  Google Scholar 

  16. Hizmetli S, Kisa M, Gokalp N, Bakici MZ (2007) Are plasma and synovial fluid leptin levels correlated with disease activity in rheumatoid arthritis? Rheumatol Int 27(4):335–338. doi:10.1007/s00296-006-0264-7

    Article  PubMed  CAS  Google Scholar 

  17. Sarraf P, Frederich RC, Turner EM et al (1997) Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 185(1):171–175. doi:10.1084/jem.185.1.171

    Article  PubMed  CAS  Google Scholar 

  18. Nishiya K, Nishiyama M, Chang A, Shinto A, Hashimoto K (2002) Serum leptin levels in patients with rheumatoid arthritis are correlated with body mass index. Rinsho Byori 50(5):524–527

    PubMed  CAS  Google Scholar 

  19. Grunfeld C, Pang M, Shigenaga JK et al (1996) Serum leptin levels in the acquired immunodeficiency syndrome. J Clin Endocrinol Metab 81(12):4342–4346. doi:10.1210/jc.81.12.4342

    Article  PubMed  CAS  Google Scholar 

  20. Popa C, Netea MG, Radstake TR, van Riel PL, Barrera P, van der Meer JW (2005) Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis. Ann Rheum Dis 64(8):1195–1198. doi:10.1136/ard.2004.032243

    Article  PubMed  CAS  Google Scholar 

  21. Tokarczyk-Knapik A, Nowicki M, Wyroślak J (2002) The relation between plasma leptin concentration and body fat mass in patients with rheumatoid arthritis. Pol Arch Med Wewn 108(2):761–767

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Cerrahpaşa Medical Faculty, İstanbul University, Istanbul, Turkey

    Arzu Seven, Savaş Güzel, Mahmure Aslan & Vedat Hamuryudan

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  1. Arzu Seven
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  2. Savaş Güzel
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  3. Mahmure Aslan
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  4. Vedat Hamuryudan
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Correspondence to Arzu Seven.

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Seven, A., Güzel, S., Aslan, M. et al. Serum and synovial fluid leptin levels and markers of inflammation in rheumatoid arthritis. Rheumatol Int 29, 743–747 (2009). https://doi.org/10.1007/s00296-008-0764-8

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  • DOI: https://doi.org/10.1007/s00296-008-0764-8

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