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A case of limited systemic sclerosis with p-ANCA, complicated by multiple cerebral hemorrhages

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Abstract

ANCA associated vasculitides are a group of disorders characterized by the presence of necrotizing inflammation of blood vessels that involve venules, capillaries, arterioles, arteries, and veins. They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCA). ANCA associated vasculitis commonly affects the kidney producing proteinuria, hematuria and variable degrees of renal failure. Other organs involved include the lung, skin and peripheral nervous system. We present a patient with limited systemic sclerosis, who later developed pauci-immune glomerulonephritis with p-ANCA (antimyeloperoxidase) specificity and, whose disease was later complicated by cerebral vasculitis with multiple intracerebral hemorrhages.

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Authors and Affiliations

  1. Pennsylvania Hospital, Philadelphia, PA, 19107, USA

    Bharath Manu Akkara Veetil

  2. Section of Rheumatology, Pennsylvania Hospital, Pennsylvania Rheumatology Associates, PC, Suite 3A, 822 Pine Street, Philadelphia, PA, 19107, USA

    Barry M. Schimmer

Authors
  1. Bharath Manu Akkara Veetil
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  2. Barry M. Schimmer
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Correspondence to Bharath Manu Akkara Veetil.

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Akkara Veetil, B.M., Schimmer, B.M. A case of limited systemic sclerosis with p-ANCA, complicated by multiple cerebral hemorrhages. Rheumatol Int 29, 325–329 (2009). https://doi.org/10.1007/s00296-008-0675-8

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  • DOI: https://doi.org/10.1007/s00296-008-0675-8

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