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Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms

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Abstract

To investigate the genotype and allele frequency of vascular endothelial growth factor gene polymorphisms in knee osteoarthritis (OA) and their relationship with disease activity and lipid profile, we enrolled 49 knee OA patients and 75 healthy subjects (HS) as a control group. Body mass index (BMI), laboratorial assessment and genotyped by polymerase chain reaction–restriction fragment length polymorphisms (PCR–RFLP) were studied in both groups. Disease activity was determined using Lequesne and WOMAC indexes; a P value < 0.05 was considered significant. The −460 and +405 VEGF polymorphisms did not shown significant association between OA patients and HS. However, between OA patients and HS a significant differences were observed in BMI, age, apo A-I and apo B, independently of both polymorphisms studied (P < 0.05). In conclusion, increased apo A-1 and apo B levels are associated in knee OA, but the −460 T/C and +405 C/G VEGF polymorphisms are not associated with knee OA susceptibility.

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Acknowledgments

This work was supported by grant no. 45703-M to JFMV of the National Council of Science and Technology (CONACyT, México-Universidad de Guadalajara).

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Authors and Affiliations

  1. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico

    Sergio Sánchez-Enríquez, Nora Magdalena Torres-Carrillo, Mónica Vázquez-Del Mercado & José Francisco Muñoz-Valle

  2. Unidad Académica de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Guadalajara, Mexico

    Lorenzo Salgado-Goytia

  3. Instituto de Genética Humana, Centro Universitario de la Ciénega, Universidad de Guadalajara, Guadalajara, Mexico

    Héctor Rangel-Villalobos

  4. Insurgentes 244-1, Colonia Lomas de Atemajac, Zapopan, Jalisco, 45178, Mexico

    José Francisco Muñoz-Valle

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  1. Sergio Sánchez-Enríquez
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  2. Nora Magdalena Torres-Carrillo
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Correspondence to José Francisco Muñoz-Valle.

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Sánchez-Enríquez, S., Torres-Carrillo, N.M., Vázquez-Del Mercado, M. et al. Increase levels of apo-A1 and apo B are associated in knee osteoarthritis: lack of association with VEGF-460 T/C and +405 C/G polymorphisms. Rheumatol Int 29, 63–68 (2008). https://doi.org/10.1007/s00296-008-0633-5

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  • DOI: https://doi.org/10.1007/s00296-008-0633-5

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