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Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis

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Abstract

In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima–media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.

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Acknowledgments

This study was supported in part by the Federico Foundation (to Y Sherer and Y Shoenfeld).

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Authors and Affiliations

  1. Department of Medicine ‘B’ and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, 52621, Tel Aviv, Israel

    Yaniv Sherer, Boris Gilburd & Yehuda Shoenfeld

  2. Department of Internal Medicine, National Referral Center for Vasculitides and Systemic sclerodermas, Hôpital Cochin, Assistance publique–Hôpitaux de Paris, Université Paris 5, Paris, France

    Christian Pagnoux, Loïc Guillevin & Luc Mouthon

  3. Department of Preventive Cardiovascular Medicine, Hôpital Broussais, Assistance publique–Hôpitaux de Paris, Université Paris 5, Paris, France

    Gilles Chironi & Alain Simon

  4. Tel Aviv University, Tel Aviv, Israel

    Yehuda Shoenfeld

Authors
  1. Yaniv Sherer
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  2. Christian Pagnoux
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  3. Gilles Chironi
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  4. Alain Simon
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  5. Loïc Guillevin
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  6. Luc Mouthon
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  7. Boris Gilburd
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  8. Yehuda Shoenfeld
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Correspondence to Yehuda Shoenfeld.

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Sherer, Y., Pagnoux, C., Chironi, G. et al. Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis. Rheumatol Int 28, 1099–1103 (2008). https://doi.org/10.1007/s00296-008-0587-7

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  • DOI: https://doi.org/10.1007/s00296-008-0587-7

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