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Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFα therapy in rheumatoid arthritis?

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Abstract

In this study we analyzed whether the polymorphisms 676T>G in the tumor necrosis factor receptor (TNFR) II gene and −308G>A in the TNFα promoter gene may influence the response grading to anti-TNFα therapy in rheumatoid arthritis. We enrolled and genotyped 105 RA patients treated with etanercept (n = 55), infliximab (n = 40) and adalimumab (n = 10) for 1 year. The clinical response was evaluated according to the ACR criteria every 3 months. Patients with TNFRII 676TG genotype was significantly associated with lower ACR response compared with 676TT genotype, at 3 (OR 3.78 95% CI 1.07–13.31) and 12 months (OR 4.30 95% CI 1.16–15.99) of treatment. No significant association between TNFα −308G>A polymorphism and the clinical response was found. TNFRII 676TG genotype is associated with a lower response to anti-TNFα therapy, independently from the specific agent used. This polymorphism could become a useful genetic marker for predicting the different response grading to anti-TNFα therapy.

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Acknowledgments

This work was supported in part by Fondazione Cassa di Risparmio di Cento, Italy.

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Authors and Affiliations

  1. Department of Morphology and Embryology, Section of Histology, University of Ferrara, Via Fossato di Mortara, 64/B, 44100, Ferrara, Italy

    Alessia Ongaro, Monica De Mattei, Agnese Pellati, Angelo Caruso & Federica Francesca Masieri

  2. Ferrara Cancer Registry, Department of Experimental and Diagnostic Medicine, Section of Anatomic Pathology, University of Ferrara, Via Fossato di Mortara, 64/B, 44100, Ferrara, Italy

    Stefano Ferretti

  3. Section of Rheumatology, Department of Clinical and Experimental Medicine, University of Ferrara, C.so Giovecca 203, 44100, Ferrara, Italy

    Maria Fotinidi, Ilaria Farina, Francesco Trotta & Melissa Padovan

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  1. Alessia Ongaro
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  2. Monica De Mattei
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Correspondence to Alessia Ongaro.

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Alessia Ongaro and Monica De Mattei contributed equally to the study.

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Ongaro, A., De Mattei, M., Pellati, A. et al. Can tumor necrosis factor receptor II gene 676T>G polymorphism predict the response grading to anti-TNFα therapy in rheumatoid arthritis?. Rheumatol Int 28, 901–908 (2008). https://doi.org/10.1007/s00296-008-0552-5

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