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Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome

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Abstract

The aberrant induction of salivary/lacrimal proteins is considered to be crucial in the pathogenesis of sicca-symptoms related to primary Sjögren syndrome (SS). We report the case of an 11-year-old boy who was admitted to hospital due to recurrent bilateral parotid gland enlargement and keratoconjunctivitis, which were diagnosed as primary SS upon a combination of laboratory and instrumental tests. The proteomic analysis of the salivary peptide complex in the patient’s salivary fluid near diagnosis and after 6 months of pharmacological therapy revealed quantitative and mostly qualitative differences. This observation reveals that clinical and functional changes of the salivary glands driven by non-steroidal antinflammatory drugs might be reflected in different proteomic patterns of the salivary fluid.

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Authors and Affiliations

  1. Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Largo A. Gemelli, 8, 00168, Rome, Italy

    Donato Rigante, Achille Stabile, Stefania Gaspari & Giuseppe Barone

  2. Institute of Clinical Biochemistry, Università Cattolica Sacro Cuore, Rome, Italy

    Rosanna Inzitari, Chiara Fanali, Ettore Capoluongo & Massimo Castagnola

  3. Pediatric Hospital Giovanni XXIII, Bari, Italy

    Maurizio Carone

  4. Department of Sciences Applied to Biosystems, Cagliari University, Cagliari, Italy

    Tiziana Cabras

Authors
  1. Donato Rigante
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  2. Rosanna Inzitari
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  3. Maurizio Carone
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  4. Chiara Fanali
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  5. Achille Stabile
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  6. Tiziana Cabras
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  7. Ettore Capoluongo
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  8. Stefania Gaspari
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  9. Giuseppe Barone
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  10. Massimo Castagnola
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Corresponding author

Correspondence to Donato Rigante.

Additional information

D. Rigante and R. Inzitari have contributed in equal parts to the preparation of the present manuscript.

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Rigante, D., Inzitari, R., Carone, M. et al. Correspondence between clinical improvement and proteomic changes of the salivary peptide complex in a child with primary Sjögren syndrome. Rheumatol Int 28, 801–806 (2008). https://doi.org/10.1007/s00296-008-0524-9

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  • DOI: https://doi.org/10.1007/s00296-008-0524-9

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