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Pathogenesis-related adhesion molecules in Henoch–Schonlein vasculitis

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Abstract

The aim of this study was to reveal the distribution of various inflammation and endothelium-related adhesion molecules, namely, P-selectin, E-selectin, ICAM-1, ICAM-2, ICAM-3 and VCAM-1, on the skin samples of patients with Henoch–Schonlein purpura. Skin biopsies obtained from 12 pediatric patients at the acute purpura phase and from 5 patients at the convalescent phase of the disease were included in the study. Endothelial expression of P-selectin (P < 0.05), endothelial and inflammatory cellular expressions of ICAM-2 (P < 0.05, P < 0.01) and inflammatory cellular expression of ICAM-3 (P < 0.05) were significantly more intense when compared to patients in the convalescent phase. Although endothelial E-selectin and VCAM-1 expressions, and endothelial and inflammatory cellular ICAM-1 expressions displayed a decrease in the convalesant phase, this difference was not found to be statistically significant (P > 0.05).

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Gulhane Military Medical Academy, School of Medicine, 06018, Etlik, Ankara, Turkey

    Faysal Gok

  2. Department of Histology-Embryology, Hacettepe University Medical Faculty, Ankara, Turkey

    Yesim Ugur & Attila Dagdeviren

  3. Department of Pediatric Nephrology and Rheumatology Unit, Hacettepe University Medical Faculty, Ankara, Turkey

    Seza Ozen

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  1. Faysal Gok
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  2. Yesim Ugur
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  3. Seza Ozen
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  4. Attila Dagdeviren
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Correspondence to Faysal Gok.

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Gok, F., Ugur, Y., Ozen, S. et al. Pathogenesis-related adhesion molecules in Henoch–Schonlein vasculitis. Rheumatol Int 28, 313–316 (2008). https://doi.org/10.1007/s00296-007-0437-z

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  • DOI: https://doi.org/10.1007/s00296-007-0437-z

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