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The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor

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Abstract

The object of this study was to determine the association of Trp64Arg polymorphism with hyperuricemia. This study is an age-matched, case-controlled study of 203 hyperuricemic and 203 normouricemic men. The frequency of genotypes was compared between the two groups. Possible confounding metabolic variables were included in a multiple logistic regression model for multivariate adjustment. The genotype frequencies of Trp64Trp, Trp64Arg, and Arg64Arg in hyperuricemic and normouricemic groups are respectively 130, 69, and 4 (64.0%, 34.0%, 2.0%) and 154, 45, and 4 (75.9%, 22.2%, 2.0%) (P = 0.029, Chi-square test). Simple logistic regression analysis indicated that the Trp64Arg genotype is significantly associated with hyperuricemia (OR = 1.816, 95% CI (1.167–2.827), P = 0.008). Multivariate analysis for controlling metabolic effects also showed a significant association with the occurrence of hyperuricemia (OR = 1.937, 95% CI (1.149–3.266), P = 0.013). Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.

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Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Guro Hospital, 97, Gurodong-Gil, Guro-Gu, 152-703, Seoul, South Korea

    Young Hee Rho, Seong Jae Choi, Young Ho Lee, Jong Dae Ji & Gwan Gyu Song

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  1. Young Hee Rho
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  2. Seong Jae Choi
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  3. Young Ho Lee
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  4. Jong Dae Ji
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  5. Gwan Gyu Song
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Correspondence to Gwan Gyu Song.

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This study was supported by the Brain Korea 21 Project in 2004.

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Rho, Y.H., Choi, S.J., Lee, Y.H. et al. The association between hyperuricemia and the Trp64Arg polymorphism of the beta-3 adrenergic receptor. Rheumatol Int 27, 835–839 (2007). https://doi.org/10.1007/s00296-006-0300-7

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