Abstract
We aimed to investigate the frequency of rheumatic diseases in patients suffering from autoimmune thyroid diseases (ATD). Sixty-five patients (56 F, 9 M), who were followed by diagnosis of ATD, were questioned and examined for the presence of rheumatic disease. Basic laboratory tests and antithyroid antibodies, antinuclear antibody and rheumatoid factor (RF) levels were also measured by appropriate methods. Various rheumatic diseases were detected in 40 (62%) of patients with ATD. The most frequent rheumatic conditions were fibromyalgia, recurrent aphthous stomatitis, osteoarthritis, keratoconjunctivitis sicca and xerostomia and carpal tunnel syndrome which were detected in 20 (31%), 13 (20%), 10 (15%), 9 (14%) and 8 (12%) of patients, respectively. Autoimmune diseases, except Sjogren’s syndrome, which were detected in ten patients with ATD, are as follows—vitiligo: two; autoimmune hepatitis: two; oral lichen planus: one, ulcerative colitis: one, inflammatory arthritis in four patients (two of them had rheumatoid arthritis, one had psoriasis and psoriatic arthritis and one had mixed collagen tissue disease). RF was positive in two patients, one of them had rheumatoid arthritis and FANA was positive in six (9%) patients; all of them had hypothyroidism. The frequency of rheumatic diseases seems to be higher in patients suffering from ATD. Initial evaluation and a regular checking for rheumatic diseases in patients suffering from ATD were recommended.
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References
Weetman AP, McGregor AM (1994) Autoimmune thyroid disease: further developments in our understanding. Endocr Rev 15:788–830
Karsh J, Pavlidis N, Weintraub BD, Moutsopoulos HM (1980) Thyroid disease in Sjogren’s syndrome. Arthritis Rheum 23:1326–1329
Weetman AP, Walport MJ (1987) The association of autoimmune thyroiditis with systemic lupus erythematosus. Br J Rheumatol 26:359–361
Pyne D, Isenberg DA (2002) Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis 61:70–72
Perez B, Kraus A, Lopez G, Cifuentes M, Alarcon-Segovia D (1995) Autoimmune thyroid disease in primary Sjogren’s syndrome. Am J Med 99(5):480–484
Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P et al (1990) The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 33(2):160–172
International Study Group for Behçet’s Disease (1990) Criteria for diagnosis of Behçet’s disease. Lancet 103:177–184
Gaches F, Delaire L, Nadalon S, Loustaud-Ratti V, Vidal E (1998) Frequency of autoimmune diseases in 218 patients with autoimmune thyroid pathologies. Rev Med Interne 19(3):173–179
Tektonidou MG, Anapliotou M, Vlachoyiannopoulos P, Moutsopoulos HM (2004) Presence of systemic autoimmune disorders in patients with autoimmune thyroid diseases. Ann Rheum Dis 63:1159–1161
Topbas M, Cakirbay H, Gulec H, Akgol E, Ak I, Can G (2005) The prevalence of fibromyalgia in women aged 20–64 in Turkey. Scand J Rheumatol 34(2):140–144
Neumann L, Buskila D (2003) Epidemiology of fibromyalgia. Curr Pain Headache Rep 7(5):362–368
Middleton GD, McFarlin JE, Lipsky PE (1994) The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus. Arthritis Rheum 37(8):1181–1188
Yavuz S, Fresko I, Hamuryudan V, Yurdakul S, Yazici H (1998) Fibromyalgia in Behcet’s syndrome. J Rheumatol 25(11):2219–2220
Cakir M, Samanci N, Balci N, Balci MK (2003) Musculoskeletal manifestations in patients with thyroid disease. Clin Endocrinol (Oxf) 59(2):162–167
Onbasi K, Sahin I, Onbasi O, Ustun Y, Koca D (2005) Raynaud’s phenomenon in a healthy Turkish population. Clin Rheumatol 24(4):365–369
Cicek Y, Canakci V, Ozgoz M, Ertas U, Canakci E (2004) Prevalence and handedness correlates of recurrent aphthous stomatitis in the Turkish population. J Public Health Dent 64(3):151–156
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Soy, M., Guldiken, S., Arikan, E. et al. Frequency of rheumatic diseases in patients with autoimmune thyroid disease. Rheumatol Int 27, 575–577 (2007). https://doi.org/10.1007/s00296-006-0263-8
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DOI: https://doi.org/10.1007/s00296-006-0263-8