Abstract
The study was designed to investigate the autonomic dysfunction in fibromyalgia syndrome (FMS) by recording sympathetic skin response (SSR) from palmar, plantar and genital regions. The second aim was to evaluate the relation between sexual problems and autonomic dysfunction in FMS. SSR potential was recorded from palmar, plantar and genital regions in 28 married, female FMS patients and 18 married, healthy females. Fibromyalgia Impact Questionnaire (FIQ) was used to show the clinical severity and functional disability in FMS patients. Glombok Rust Inventory of Sexual Satisfaction (GRISS), a 28-item questionnaire, was used to assess the existence and severity of sexual problems. Beck test was used to evaluate anxiety and depression. The amplitude of SSR recorded from palmar, plantar and genital regions was lower than in the control subjects (P < 0.05). GRISS (total and subscale), Beck test and FIQ scores of FMS patients were higher than in the control subjects (P < 0.05). No correlation was found between the SSR potential and GRISS scores. The results of our study reveal that abnormality in SSR recorded from palmar, plantar and genital regions reflects the abnormality in the autonomic nervous system (ANS) of FMS patients. These patients have more sexual problems than healthy subjects, and we think this finding is related to increased anxiety and depression in these patients.
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References
Bou-Holaigah I, Calkins H, Flynn JA et al (1997) Provocation of hypotension and pain during upright tilt table testing in adults with fibromyalgia. Clin Exp Rheumatol 15:239–246
Naschitz JE, Rozenbaum M, Rosner I et al (2001) Cardiovascular response to upright tilt in fibromyalgia differs from that in chronic fatigue syndrome. J Rheumatol 28:1356–1360
Martinez-Lavin M, Hermosillo AG (2000) Autonomic nervous system dysfunction may explain the multisystem features of fibromyalgia. Semin Arthritis Rheum 29(4):197–199
Vaeroy H, Qiao ZG, Morkrid L et al (1989) Altered sympathetic nervous system response in patients with fibromyalgia (fibrositis syndrome). J Rheumatol 16:1460–1465
Qiao ZG, Vaeroy H, Morkrid L (1991) Electrodermal and microcirculatory activity in patients with fibromyalgia during baseline, acoustic stimulation and cold pressor tests. J Rheumatol 18:1383–1389
Cohen H, Neuman L, Shore M et al (2000) Autonomic dysfunction in patients with fibromyalgia: application of power spectrum analysis of heart rate variability. Semin Arthritis Rheum 29:217–227
Raj SR, Brouillard D, Simpson C et al (2000) Dysautonomia among patients with fibromyalgia: a noninvasive assessment. J Rheumatol 27:2600–2605
Müslumanoglu l, Akyuz G, Aki S et al (2002) Evaluation of autonomic nervous system functions in post-stroke patients. Am J Phys Med Rehabil 81:721–725
Ulas UH, Unlu E, Hamamcioglu K, Odabasi Z, Cakci A, Vural O (2005) Dysautonomia in fibromyalgia syndrome: sympathetic skin responses and RR interval analysis’. Rheumatol Int 30:1–5
Clinchot DM, Lorch F (1996) Sympathetic skin response in patients with reflex sympathetic dystrophy. Am J Phys Med Rehabil 75(4):252–256
Akyuz G, Sozuer TD, Turan B et al (1999) Normative data of sympathetic skin response and RR interval variation in Turkish children. Brain Dev 21:99–102
Satchell PM, Seers CP (1987) Evoked skin sympathetic nerve responses in man. J Neurol Neurosurg Psychiatry 50:1015–1021
Yılmaz U, Soylu A, Ozcan C et al (2002) Clitoral electromyography. J Urol 167:616–620
Basson R (2002) A model of women’s sexual arousal. J Sex Marital Ther 28:1–10
Traish AM, Kim NN, Munarriz R et al (2002) Biomechanical and physiological mechanisms of female genital sexual arousal. Arch Sex Behav 31(5):393–400
Tıkız C, Müezzinoglu T, Pirildar T et al (2005) Sexual dysfunction in female subjects with fibromyalgia. J Urol 174(2):620–623
Wolfe F, Smythe HA, Yunus MB et al (1990) American College of Rheumatology 1990 criteria for the classification of fibromyalgia: report of the Multicenter Criteria Committee. Arthritis Rheum 33:160–172
Sarmer S, Ergin S, Yavuzer G (2000) The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int 20:9–12
Rust J, Golombok S (1986) The GRISS: a psychometric instrument for the assessment of sexual dysfunction. Arch Sex Behav 15(2):157–165
Beck AT, Steer RA, Gorbin MG (1988) Psychometric properties of the Beck Depression Inventory. Twenty five years of evaluation. Clin Psychol Rev 8:77–100
Neeck G (2002) Pathogenic mechanisms of fibromyalgia. Ageing Res Rev 1:243–255
Shahani BT, Day TJ, Cros D et al (1990) RR interval variation and the sympathetic skin response in the assessment of autonomic function in peripheral neuropathy. Arch Neurol 47:659–664
Kadri N, McHichi Alami KH, McHakra Tahiri S (2002) Sexual dysfunction in women: population based epidemiological study. Arch Women Ment Health 5:59–63
Aksaray G, Yelken B, Kaptanoglu C et al (2001) Sexuality in women with obsessive compulsive disorder. J Sex Marital Ther 27:273–277
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The authors thank Dr. Zekeriyya Alanoglu for the statistical analysis.
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Ünlü, E., Ulaş, Ü.H., Gürçay, E. et al. Genital sympathetic skin responses in fibromyalgia syndrome. Rheumatol Int 26, 1025–1030 (2006). https://doi.org/10.1007/s00296-006-0131-6
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DOI: https://doi.org/10.1007/s00296-006-0131-6