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Plasma interleukin-10 and interleukin-12 levels in patients with familial Mediterranean fever

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Abstract

Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterized by recurrent attacks of fever, polyserositis and arthritis. A vast array of cytokines were analysed in these patients, however, little is known about the pro-inflammatory cytokine interleukin (IL)-12. Plasma IL-12 and IL-10 were measured in 24 patients with FMF (19 active, 5 inactive) and 18 healthy controls by ELISA. From 15 active patients blood was also drawn in attack-free period. Mean plasma IL-12 levels of the FMF patients (mean ± SEM, 6.84±3.59 pg/ml) were higher than the controls (0.13±0.09 pg/ml, P<0.001). Mean IL-12 levels of active (7.02±5.23 pg/ml) and inactive patients (6.89±5.61 pg/ml) were comparable, and they were higher compared to controls (P≤0.001). Mean plasma IL-10 levels of the total FMF patients (3.01±1.53 pg/ml) were also higher than the controls (P=0.024). Patients had higher IL-10 levels in attacks (3.83±2.02 pg/ml) compared to levels when they were in remission (1.86±1.59 pg/ml, P=0.046). Significantly elevated IL-12 levels in FMF patients regardless of activity may suggest the presence of a pro-inflammatory state also in the inactive period of FMF. Significant increase in IL-10 levels in FMF group may point to the compensatory suppression of inflammation in active periods of the disease.

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Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology–Immunology, Faculty of Medicine, Cukurova University, Balcali, P.O. Box (PK) 5, 01330, Adana, Turkey

    Eren Erken, Huseyin T. E. Ozer & Ramazan Gunesacar

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  1. Eren Erken
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  2. Huseyin T. E. Ozer
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  3. Ramazan Gunesacar
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Correspondence to Eren Erken.

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Erken, E., Ozer, H.T. & Gunesacar, R. Plasma interleukin-10 and interleukin-12 levels in patients with familial Mediterranean fever. Rheumatol Int 26, 862–864 (2006). https://doi.org/10.1007/s00296-005-0099-7

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  • DOI: https://doi.org/10.1007/s00296-005-0099-7

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