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The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis

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Abstract

The effects of a new generation bisphosphonate, incadronate, in established adjuvant arthritis rats were evaluated according to the arthritis index, hind paw volume, and radiological and histopathological examinations. Incadronate suppressed the radiological and histopathological changes of hind paws, as well as the joint swelling in a dose-dependent manner. In contrast, the arthritis control rats showed drastic joint inflammation, marked destruction of bone and articular cartilage. The remains of articular cartilage lost Safranin O staining, and were attached with numerous TRAP-positive multinuclear cells. Some of resorption lacunas could be seen at the cartilage matrix nearby the TRAP-positive multinuclear cells. As regards the chondroprotective effects of bisphosphonates, we speculate that it is probably concerned with the inhibition of the chondroclasts. These data indicate that bisphosphonates may be a class of effective agent that can be considered for treatment of various arthritic conditions, including human rheumatoid arthritis.

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Acknowledgments

The authors thank Yamanouchi Pharmaceutical CO., Ltd., for kindly providing incadronate (YM175), and Mr. Takaaki Kanemaru, Mr. Masaharu Magara and Miss Naoko Tanaka for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, China

    Hongpu Zhao, Shangli Liu & Dongsheng Huang

  2. Department of Outpatient, The 1st Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 10 Jichang Road, Guangzhou, 510405, China

    Qiuyu Xu

  3. Department of Orthopaedic Surgery, Graduate School of Medicinal Science, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan

    Toshihide Shuto & Yukihide Iwamoto

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  1. Hongpu Zhao
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  2. Shangli Liu
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  3. Dongsheng Huang
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  4. Qiuyu Xu
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  5. Toshihide Shuto
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  6. Yukihide Iwamoto
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Correspondence to Hongpu Zhao.

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Zhao, H., Liu, S., Huang, D. et al. The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis. Rheumatol Int 26, 732–740 (2006). https://doi.org/10.1007/s00296-005-0061-8

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  • DOI: https://doi.org/10.1007/s00296-005-0061-8

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