Abstract
Histiocytic necrotizing lymphadenitis, called Kikuchi-Fujimoto’s disease (KFD), is an idiopathic, self-limited condition rarely associated with systemic lupus erythematosus (SLE). The cause of concomitant KFD and SLE is still unknown. We describe a 19-year-old man simultaneously diagnosed with both KFD and SLE complicated with deep vein thrombosis (DVT). To the best of our knowledge, this is the first case report of KFD associated with SLE complicated with antiphospholipid antibody syndrome (APS). Our patient was successfully treated with intravenous pulse methylprednisolone, anticoagulation with heparin, oral hydroxychloroquine, azathioprine, and low-dose aspirin.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Dorfman RF, Berry GJ (1988) Kikuchi histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 5:329–345
Martinez-Vazauez C, Hughes G, Bordon J, Alonso-Alonso J, Anibarro-Garcia A, Redondo-Martinez E (1997) Histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto’s disease, associated with systemic lupus erythematosus. Q J Med 90:531–533
Kuo TT (1995) Kikuchi’s disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtype, immunohistology and DNA ploidy. Am J Surg Pathol 19:798–809
Spies J, Foucar K, Thompson CT, LeBoit PE (1999) The histopathology of cutaneous lesions of Kikuchi’s disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol 23:1040–1047
Fox RA, Rosahn PD (1943) The lymph nodes in disseminated lupus erythematosus. Am J Pathol 19:73–99
Pai MR, Adhikari P, Coimbatore RV, Ahmed S (2000) Fine needle aspiration cytology in systemic lupus erythematosus lymphadenopathy. A case report. Acta Cytol 44:67–69
Provenzale JM, Ortel TL, Allen NB (1998) Systemic thrombosis in patients with antiphospholipid antibodies: lesion distribution and imagine findings. AJR 170:285–290
Vila LM, Mayor AM, Silvestrini IE (2001) Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi’s disease. Lupus 10:126–128
Meyer O, Kahn MF, Grossin M, Ribard P, Belmatoug N, Morinet F, Fournet JC (1991) Parvovirus B19 infection can induce histiocytic necrotizing lymphadenitis (KiKuchi’s disease) associated with systemic lupus erythematosus. Lupus 1:37–41
Litwin MD, Kirkham B, Henderson DRF, Milazzo SC (1992) Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 51:805–807
Hoffman A, Kirn K, Kuerten A, Sander C, Krueger GR, Ablashi D (1991) Active hyman herpesvirus-6 (HHV-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus. In Vivo 5:265–269
Eisner MD, Amory J, Mullaney B, Tierney L Jr, Browner WS (1996) Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 26:477–482
Chen YH, Lan JL (1998) Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 31:187–192
Dalkilic E, Karakoc Y, Tolunay S, Yurtkuran M (2001) Systemic lupus erythematosus presenting as Kikuchi-Fujimoto disease. Clin Exp Rheum 19:226
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chen, HC., Lai, JH., Huang, GS. et al. Systemic lupus erythematosus with simultaneous onset of Kikuchi-Fujimoto’s disease complicated with antiphospholipid antibody syndrome: a case report and review of the literature. Rheumatol Int 25, 303–306 (2005). https://doi.org/10.1007/s00296-004-0507-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-004-0507-4