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Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?

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Abstract

Our aim was to investigate the effects of hyaluronan on inflammatory cytokines in the synovial fluid of patients with knee osteoarthritis. The study was single blind, placebo-controlled, and randomized. We administered hyaluronan to 22 patients in the study group and placebo to 19 in the control group. Enzyme-linked immunosorbent assay was used to determine the levels of cytokines. Both HA and placebo caused a significant decrease in interleukin (IL)-6 levels (P=0.0001 and P=0.04, respectively). But it was more significant in the study group. However, IL-8 and tumor necrosis factor alpha (TNF-α) levels did not change in either group (P>0.05). The amount of effusion decreased significantly in the study group (P=0.001) but not in the control group (P=0.133). It can be concluded that hyaluronan considerably decreased IL-6 levels, which correlated with clinical improvement, but had no effect on IL-8 and TNF-α levels in synovial fluid. However, larger studies with longer follow-up periods are needed to explain the effect of hyaluronan on cytokines.

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Authors and Affiliations

  1. Department of Physical Therapy and Rehabilitation, SSK 70 Years Hospital, Tarsus, Mersin, Turkey

    Melek Sezgin

  2. Department of Physical Therapy and Rehabilitation, SSK Ankara Education Hospital, Ankara, Turkey

    Alev Çevikol Demirel, Cevriye Karaca, Özgür Ortancıl & Aytül Çakçı

  3. Department of Microbiology, SSK Ankara Education Hospital, Ankara, Turkey

    Gül Bahar Ülkar

  4. Department of Biostatistics, Mersin University Medical Faculty, Mersin, Turkey

    A. Kanık

  5. Hürriyet mh. 1756 sk., Mahmut Hayfavi Ap. No:18, Mersin, Turkey

    Melek Sezgin

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  1. Melek Sezgin
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  2. Alev Çevikol Demirel
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  3. Cevriye Karaca
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  4. Özgür Ortancıl
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  5. Gül Bahar Ülkar
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Correspondence to Melek Sezgin.

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Sezgin, M., Demirel, A.Ç., Karaca, C. et al. Does hyaluronan affect inflammatory cytokines in knee osteoarthritis?. Rheumatol Int 25, 264–269 (2005). https://doi.org/10.1007/s00296-003-0428-7

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  • DOI: https://doi.org/10.1007/s00296-003-0428-7

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