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The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide

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Abstract

ATP citrate lyase (ACL) catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols. In this paper, we show for the first time that in filamentous fungi two different subunits of ACL are encoded by two separate genes. This is in contrast to animals where ACL is encoded by a single gene. Data are presented on acl genes from the filamentous fungi Sordaria macrospora and Gibberella pulicaris. In S. macrospora, both genes, acl1 and acl2, are clustered within a region of 10 kb and are divergently transcribed.

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Authors and Affiliations

  1. Lehrstuhl für Allgemeine und Molekulare Botanik, Ruhr-Universität Bochum, 44780 Bochum, Germany e-mail: ulrich.kueck@ruhr-uni-bochum.de Tel.: +49 234 32-26212; Fax: +49 234 3214-184, , , , , , DE

    Minou Nowrousian & Ulrich Kück

  2. Institut für Botanik und Botanischer Garten, Universität Münster, 48149 Münster, , , , , , DE

    Karin Loser & Klaus-Michael Weltring

Authors
  1. Minou Nowrousian
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  2. Ulrich Kück
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  3. Karin Loser
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  4. Klaus-Michael Weltring
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Received: 13 September / 2 November 1999

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Nowrousian, M., Kück, U., Loser, K. et al. The fungal acl1 and acl2 genes encode two polypeptides with homology to the N- and C-terminal parts of the animal ATP citrate lyase polypeptide. Curr Genet 37, 189–193 (2000). https://doi.org/10.1007/s002940050518

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  • DOI: https://doi.org/10.1007/s002940050518

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