Abstract
Discovery of prions—proteins that are able to convert between structurally distinct states, of which one or more is transmissible, led to the concept of “protein-based inheritance”. According to this concept, the formation of prion fibrils causes DNA-independent heritable traits in microorganisms. Recently, we described a new and unusual type of prion inheritance. We showed that the yeast prions [PIN +] and [SWI +], like classical genes, demonstrate complementary interaction that causes a phenotypic change in yeast cells. Here, we discuss the possible mechanisms of such polyprionic inheritance and the perspectives in the identification of prions in various organisms using universal proteomic approaches.
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Acknowledgements
I am grateful to N. Degtyareva, A. Maltseva, J. Sopova, and S Zadorsky for the critical reading and help in the preparation of the manuscript. This work was supported by the Russian Science Foundation (14-50-00069 to SPbSU) and by SPbSU (grant for A.P.G.).
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Communicated by M. Kupiec.
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Galkin, A.P. Prions and the concept of polyprionic inheritance. Curr Genet 63, 799–802 (2017). https://doi.org/10.1007/s00294-017-0685-8
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DOI: https://doi.org/10.1007/s00294-017-0685-8