Zusammenfassung
Das plasmazytoide Urothelkarzinom (PUC) stellt eine seltene Variante des Urothelkarzinoms mit charakteristischen histopathologischen und klinischen Eigenschaften dar. Die Inzidenz beträgt zwischen 2,7 und 3,1% der muskelinvasiven Urothelkarzinome. Diese Form entspricht einem aggressiven, häufig lokal fortgeschrittenen „High-grade-Tumor“ mit schlechter Prognose. Eine negative E-Cadherin-Expression scheint für eine exakte Diagnose von Bedeutung zu sein. Eine systemische Chemotherapie könnte in der Behandlung des PUC zu einem verlängerten Überleben der Patienten führen.
Abstract
Plasmacytoid carcinoma is a rare variant of urothelial carcinoma and is characterised by distinct histopathological and clinical characteristics. The incidence varies between 2.7% and 3.1% of all muscle-invasive urothelial carcinoma. It is an aggressive, high-grade tumor with poor prognosis. Negative E-cadherin expression seems to be important for exact diagnosis. Systemic chemotherapy of plasmacytoid carcinoma could lead to prolonged patient survival.
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Keck, B., Stöhr, R., Goebell, P. et al. Das plasmazytoide Urothelkarzinom. Pathologe 29, 379–382 (2008). https://doi.org/10.1007/s00292-008-1017-z
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DOI: https://doi.org/10.1007/s00292-008-1017-z