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Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier

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Abstract

As a kind of novel hydrophobic drug carrier materials, the drug-loaded nanofibers were successfully fabricated using amphiphilic alginate derivative (AAD) and poly (vinyl alcohol) (PVA) by electrospinning method. The AAD was synthesized by amide linkage attachment of octylamine onto the carboxylic group of alginate, which was characterized by the means of elemental analysis, FT-IR spectrometer, 1H NMR spectrometer and fluorescence measurement. Experimental results showed the amidation of alginate was successful, in which the degree of modification was 0.27 and the critical aggregation concentration in 0.15 mol/L aqueous NaCl solution was 0.43 mg/mL. The octyl groups of AAD could effectively make alginate chains flexible and enhance chain entanglements through the hydrophobic interactions between octyl groups. In contrast to sodium alginate (SA)/PVA blend solutions, AAD/PVA blend solutions showed more excellent electrospinnability. Additionally, the different volume ratios of SA or AAD to PVA played an important role in the formation and morphology of the electrospun blend nanofibers. Although the amidation of alginate could not fundamentally alter the spinnability of alginate, the content of alginate in the blend nanofibers was appropriately increased. The new generated drug-loaded AAD/PVA (20/80) blend nanofibers exhibited relatively continuous and uniform nanofibers with the average diameter of 191.72 nm. Compared to the drug-loaded SA/PVA (20/80) blend nanofibers, the drug-loaded AAD/PVA (20/80) blend nanofibers presented a sustained release performance with the slow release of about 76 % λ-cyhalothrin during the initial period of 10 h.

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Acknowledgments

We gratefully thank the financial support form the National Natural Science Foundation of China (21366010), Hainan Province Fund (213010), Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2011BAE06B06-07).

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571100, Hainan, People’s Republic of China

    Xiuqiong Chen, Huiqiong Yan, Wei Sun, Qiang Lin, Zaifeng Shi & Xianghui Wang

  2. Key Laboratory of Ministry of Education for Application Technology of Chemical Materials in Hainan Superior Resources, College of Materials and Chemical Engineering, Hainan University, Haikou, 570228, People’s Republic of China

    Yuhong Feng & Jiacheng Li

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  1. Xiuqiong Chen
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Correspondence to Jiacheng Li or Qiang Lin.

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Chen, X., Yan, H., Sun, W. et al. Synthesis of amphiphilic alginate derivatives and electrospinning blend nanofibers: a novel hydrophobic drug carrier. Polym. Bull. 72, 3097–3117 (2015). https://doi.org/10.1007/s00289-015-1455-8

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  • DOI: https://doi.org/10.1007/s00289-015-1455-8

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