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Colorimetric chemosensor for ATP based on phthalimide-appended poly(2,5-dimethoxyaniline)

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Abstract

We have designed a colorimetric conjugated polymer (PDMAp) for selective ATP sensing based on poly(2,5-dimethoxyaniline) bearing phthalimide which can form hydrogen bonds with adenine. PDMAp have been synthesized via chemical oxidative polymerization with CSA and DDQ and dedoping with an aqueous ammonia solution. PDMAp was displayed to signal the colorimetric selective detection for ATP over various nucleotides such as ADP, AMP, CTP, TTP, and GTP in DMSO–water (9:1, v/v) mixture. The absorption spectral change can be attributed to a doping process of ATP to PDMAp through hydrogen bonds between phthalimide and adenine as well as electrostatic interactions between the phosphate group of ATP and the backbone of PDMAp.

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Authors and Affiliations

  1. Department of Biological Applied Chemistry, Graduate School of Engineering, Toyo University, 2100 Kujirai, Kawagoe, Saitama, 350-8585, Japan

    Akinori Kato & Yasumasa Fukushima

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  1. Akinori Kato
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  2. Yasumasa Fukushima
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Correspondence to Yasumasa Fukushima.

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Kato, A., Fukushima, Y. Colorimetric chemosensor for ATP based on phthalimide-appended poly(2,5-dimethoxyaniline). Polym. Bull. 70, 3519–3527 (2013). https://doi.org/10.1007/s00289-013-1037-6

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  • DOI: https://doi.org/10.1007/s00289-013-1037-6

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