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pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system

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Abstract

Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments. The release kinetic tests were conducted using a buffer solution as the release medium under pH conditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel–solution contact. The overall rate of amoxicillin release was represented with a two-parameter empirical model as a function of time.

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Acknowledgments

C. J. Pérez-Martínez acknowledges CONACYT (Consejo Nacional de Ciencia y Tecnología, México) for the financial support provided for her graduate studies during this study.

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Authors and Affiliations

  1. Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, Rosales y Luis Encinas s/n, Colonia centro, Hermosillo, Sonora, 83000, México

    D. E. Rodríguez-Félix, C. J. Pérez-Martínez, M. M. Castillo-Ortega & T. Del Castillo-Castro

  2. Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora, Rosales y Luis Encinas s/n, Colonia centro, Hermosillo, Sonora, 83000, México

    M. Pérez-Tello

  3. Centro de Investigación en Química Aplicada, Blvd. Enrique Reyna #140, Saltillo, Coahuila, 25100, México

    J. Romero-García & A. S. Ledezma-Pérez

  4. Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, Rosales y Luis Encinas s/n, Colonia centro, Hermosillo, Sonora, 83000, México

    F. Rodríguez-Félix

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  1. D. E. Rodríguez-Félix
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  2. C. J. Pérez-Martínez
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  3. M. M. Castillo-Ortega
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  4. M. Pérez-Tello
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  5. J. Romero-García
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  6. A. S. Ledezma-Pérez
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  7. T. Del Castillo-Castro
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  8. F. Rodríguez-Félix
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Correspondence to D. E. Rodríguez-Félix.

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Rodríguez-Félix, D.E., Pérez-Martínez, C.J., Castillo-Ortega, M.M. et al. pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system. Polym. Bull. 68, 197–207 (2012). https://doi.org/10.1007/s00289-011-0549-1

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  • DOI: https://doi.org/10.1007/s00289-011-0549-1

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