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Controlled release of 5-aminosalicylic acid from a new pH responsive polymer derived from tamarind seed polysaccharide, acrylic acid, and polyamidoamine

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Abstract

A new pH-responsive polymer (TKP–AA–PAA) was synthesized from the combination of tamarind kernel powder (TKP), acrylic acid (AA), and polyamidoamine (PAA) which was utilized for controlled release of 5-aminosalicylic acid (5-ASA) in buffer medium. The network structure of TKP–AA–PAA was obtained by irradiating the mixture of TKP, AA, and PAA in different proportion in presence of 2,2-dimethoxy-2-phenyl acetophenone as a photoinitiator. The dynamic and equilibrium swelling properties of the polymeric materials were studied as a function of pH and time in different buffer solutions similar to that of gastric and intestinal fluids. The controlled release kinetics of 5-ASA in simulated body fluid showed a Fickian diffusion behavior.

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Acknowledgment

R.K.D. is thankful to Professor A. R. Ray for useful discussions. Kind help of CIF, BIT, Mesra, is thankfully acknowledged.

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Authors and Affiliations

  1. Post Graduate Department of Chemistry, Ravenshaw University, Cuttack, 753 003, Orissa, India

    R. K. Dey & Tanushree Patnaik

  2. Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi, 835 215, India

    G. S. Tiwary & Usha Jha

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  1. R. K. Dey
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  2. G. S. Tiwary
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  3. Tanushree Patnaik
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  4. Usha Jha
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Correspondence to R. K. Dey.

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Dey, R.K., Tiwary, G.S., Patnaik, T. et al. Controlled release of 5-aminosalicylic acid from a new pH responsive polymer derived from tamarind seed polysaccharide, acrylic acid, and polyamidoamine. Polym. Bull. 66, 583–598 (2011). https://doi.org/10.1007/s00289-010-0294-x

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  • DOI: https://doi.org/10.1007/s00289-010-0294-x

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