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Fabrication of core–shell hybrid nanoparticles by mineralization on poly(ε-caprolactone)-b-poly(methacrylic acid) copolymer micelles

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Abstract

Polymer micelles containing calcium phosphate (CaP) minerals on the shell domain were developed by nanotemplate-driven mineralization. The polymer micelle nanotemplate was prepared by self-assembly of a poly(ε-caprolactone)-b-poly(methacrylic acid) (PCL-b-PMAA) copolymer. PMAA formed the anionic outer shell, and PCL constructed the hydrophobic inner core. Subsequent addition of calcium and phosphate ions to micellar solutions induced CaP mineral deposition within the PMAA shell domain. Transmission electron microscopy (TEM) showed the well-defined nanostructure consisting of the CaP nanoshell and the PCL inner core. Energy-dispersive X-ray spectroscopy (EDS) confirmed CaP deposition on polymer micelles. Dynamic light scattering (DLS) study showed CaP mineralization greatly enhanced the micellar stability.

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Acknowledgments

This research was supported by a grant from “the fundamental R&D Program for Core Technology of Materials” funded by Ministry of Knowledge Economy, Republic of Korea (K0006028), and a Grant (code #: 2010K000296) from “Center for Nanostructured Materials Technology” under “21st Century Frontier R&D Programs” of the Ministry of Education, Science and Technology, Republic of Korea.

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Authors and Affiliations

  1. Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul, 130-701, Korea

    Hong Jae Lee & Sang Cheon Lee

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  1. Hong Jae Lee
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  2. Sang Cheon Lee
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Correspondence to Sang Cheon Lee.

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Lee, H.J., Lee, S.C. Fabrication of core–shell hybrid nanoparticles by mineralization on poly(ε-caprolactone)-b-poly(methacrylic acid) copolymer micelles. Polym. Bull. 65, 743–752 (2010). https://doi.org/10.1007/s00289-010-0290-1

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  • DOI: https://doi.org/10.1007/s00289-010-0290-1

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