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pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior

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Abstract

pH Sensitive poly(acryl amide-co-2-acrylamido-2-methyl-1-propanesulfonic acid-co-acrylamidoglycolic acid) hydrogels were synthesized by free-radical copolymerization. These hydrogels were prepared with different ratios of monomers and a crossliker. These hydrogels were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The diffusional exponent (n) values of synthesized hydrogels were found to be in the range between 0.49 and 0.59, indicating a quasi-Fickian diffusion mechanism with partly chain relaxation controlled diffusion. The hydrogels demonstrated a sharp change in its water absorbency and molecular weight between crosslinks of the network with a change in pH of the swelling media. 5-fluorouracil has been used as a model drug to study the drug release capability of these hydrogels.

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Acknowledgments

The study was financially supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Laboratory Program funded by the Ministry of Science and Technology (MOST; M10300000369-06J0000-36910), the SRC/ERC program of MOST/KOSEF(grant # R11-2000-070-080020) and the Brain Korea 21 project.

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  1. K. S. V. Krishna Rao

    Present address: Department of Chemistry, Yogi Vemana University, Vemana Puram, Kadapa, 516 003, India

Authors and Affiliations

  1. Department of Polymer Science and Engineering, Pusan National University, Busan, 609-735, South Korea

    K. S. V. Krishna Rao & Chang-Sik Ha

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  1. K. S. V. Krishna Rao
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  2. Chang-Sik Ha
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Correspondence to K. S. V. Krishna Rao or Chang-Sik Ha.

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Krishna Rao, K.S.V., Ha, CS. pH Sensitive hydrogels based on acryl amides and their swelling and diffusion characteristics with drug delivery behavior. Polym. Bull. 62, 167–181 (2009). https://doi.org/10.1007/s00289-008-0011-1

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