Abstract
We model electrical wave propagation in a ring of cardiac tissue using an mth-order difference equation, where m denotes the number of cells in the ring. Under physiologically reasonable assumptions, the difference equation has a unique equilibrium solution. Applying Jury’s stability test, we prove a theorem concerning the local asymptotic stability of this equilibrium solution. Our results yield conditions for sustained reentrant tachycardia, a type of cardiac arrhythmia.
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References
Åström K.J. and Wittenmark B. (1984). Computer Controlled Systems: Theory and Design. Prentice-Hall, New Jersey
Cain J.W. and Schaeffer D.G. (2006). Two-term asymptotic approximation of a cardiac restitution curve. SIAM Rev. 48: 37–546
Cain J.W., Tolkacheva E.G., Schaeffer D.G. and Gauthier D.J. (2004). Rate-dependent propagation of cardiac action potentials in a one-dimensional fiber. Phys. Rev. E 70: 061906
Cherry E.M. and Fenton F.H. (2004). Suppression of alternans and conduction blocks despite steep APD restitution: Electrotonic, memory and conduction velocity restitution effects. Am. J. Physiol. 286: H2332–H2341
Chialvo D.R., Michaels D.C. and Jalife J. (1990). Supernormal excitability as a mechanism of chaotic dynamics of activation in cardiac Purkinje fibers. Circ. Res. 66: 525–545
Courtemanche M., Keener J.P. and Glass L. (1996). A delay equation representation of pulse circulation on a ring in excitable media. SIAM J. Appl. Math. 56: 119–142
Cytrynbaum E. and Keener J.P. (2002). Stability conditions for the traveling pulse: Modifying the restitution hypothesis. Chaos 12: 788–799
Elaydi S.N. (1999). An Introduction to Difference Equations, 2nd edn. Springer, New York
Elharrar V. and Surawicz B. (1983). Cycle length effect on restitution of action potential duration in dog cardiac fibers. Am. J. Physiol. Heart Circ. Physiol. 244: H782–H792
Fenton F. and Karma A. (1998). Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation. Chaos 8: 20–47
Fox J.J., Gilmour R.F. and Bodenschatz E. (2002). Conduction block in one dimensional heart fibers. Phys. Rev. Lett. 89: 198101–198104
Frame L.H. and Simson M.B. (1988). Oscillations of conduction, action potential duration and refractoriness: A mechanism for spontaneous termination of reentrant tachycardias. Circulation 78: 1277–1287
Hall G.M., Bahar S. and Gauthier D.J. (1999). Prevalence of rate-dependent behaviors in cardiac muscle. Phys. Rev. Lett. 82: 2995–2998
Hurwitz A. (1964). On the Conditions Under Which an Equation has Only Roots with Negative Real Parts. In: Bellman, R. and Kalaba, R. (eds) Selected Papers on Mathematical Trends in Control Theory, vol. 65., pp. Dover, New York
Ito H. and Glass L. (1992). Theory of reentrant excitation in a ring of cardiac tissue. Physica D 56: 84–106
Jury, E.I., Blanchard, J.: A stability test for linear discrete systems in table form. In: Proceedings of the IRE, vol. 49, pp. 1947–1948 (1961)
Kalb S.S., Dobrovolny H.M., Tolkacheva E.G., Idriss S.F., Krassowska W. and Gauthier D.J. (2004). The restitution portrait: A new method for investigating rate-dependent restitution. J. Cardiovasc. Electrophysiol. 15: 698–709
Karma A. (1993). Spiral breakup in model equations of action potential propagation in cardiac tissue. Phys. Rev. Lett. 71: 1103–1107
Karma A. (1994). Electrical alternans and spiral wave breakup in cardiac tissue. Chaos 4: 461–472
Keener J.P. (1980). Waves in excitable media. SIAM J. Appl. Math. 39: 528–548
Keener J.P. and Sneyd J. (1998). Mathematical Physiology. Springer, New York
Luo C. and Rudy Y. (1994). A dynamic model of the cardiac ventricular action potential. Circ Res 74: 1071–1096
Mitchell C.C. and Schaeffer D.G. (2003). A two-current model for the dynamics of cardiac membrane. Bull. Math. Biol. 65: 767–793
Neu J.C., Preissig R.S. and Krassowska W. (1997). Initiation of propagation in a one-dimensional excitable medium. Physica D 102: 285–299
Nolasco J.B. and Dahlen R.W. (1968). A graphic method for the study of alternation in cardiac action potentials. J. Appl. Physiol. 25: 191–196
Ohara T., Ohara K., Cao J., Lee M., Fishbein M.C., Mandel W.J., Chen P. and Karagueuzian H.S. (2001). Increased wave break during ventricular fibrillation in the epicardial border zone of hearts with healed myocardial infarction. Circulation 103: 1465–1472
Plonsey R. and Barr R.C. (1988). Bioelectricity: A Quantitative Approach. Plenum Press, New York
Rinzel, J., Maginu, K.: Kinematic analysis of wave pattern formation in excitable media. In: Pacault, A., Vidal, C. (eds.) Non-Equilibrium Dynamics in Chemical Systems. Springer, Berlin (1984)
Rosenbaum D.S., Jackson L.E., Smith J.M., Garan H., Ruskin J.N. and Cohen R.J. (1994). Electrical alternans and vulnerability to ventricular arrhythmias. N. Engl. J. Med. 330: 235–241
Schaeffer, D.G., Cain, J.W., Gauthier, D.J., Kalb, S.S., Krassowska, W., Oliver, R.A., Tolkacheva, E.G., Ying, W.: An ionically based mapping model with memory for cardiac restitution. Bull. Math. Biol. (to appear) (2006)
Sedaghat H., Kent C.M. and Wood M.A. (2005). Criteria for the convergence, oscillation and bistability of pulse circulation in a ring of excitable media. SIAM J. Appl. Math. 66: 573–590
Sedaghat, H., Baumgarten, C., Cain, J.W., Chan, D.M., Cheng, C.K., Kent, C.M., Wood, M.A.: Modeling spontaneous initiation and termination of reentry in cardiac tissue. In: Dynamics Days 2007: International Conference on Chaos and Nonlinear Dynamics, Boston, 3–6 January 2007
Stubna M.D., Rand R.H. and Gilmour R.F. (2002). Analysis of a nonlinear partial difference equation and its application to cardiac dynamics. J. Differ. Equ. Appl. 8: 1147–1169
Tolkacheva E.G., Schaeffer D.G., Gauthier D.J. and Krassowska W. (2003). Condition for alternans and stability of the 1:1 response pattern in a “memory” model of paced cardiac dynamics. Phys. Rev. E 67: 031904
Tolkacheva E.G., Schaeffer D.G., Gauthier D.J. and Mitchell C.C. (2002). Analysis of the Fenton-Karma model through an approximation by a one-dimensional map. Chaos 12: 1034–1042
Watanabe M.A., Fenton F.H., Evans S.J., Hastings H.M. and Karma A. (2001). Mechanisms for discordant alternans. J. Cardiovasc. Electrophysiol. 12: 196–206
Yehia A.R., Jeandupeux D., Alonso F. and Guevara M.R. (1999). Hysteresis and bistability in the direct transition from 1:1 to 2:1 rhythm in periodically driven single ventricular cells. Chaos 9: 916–931
Zaitsev A.V., Berenfeld O., Mironov S.F., Jalife J. and Pertsov A.M. (2000). Distribution of excitation frequencies on the epicardial and endocardial surfaces of fibrillating ventricular wall of the sheep heart. Circ. Res. 86: 408–417
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Cain, J.W. Criterion for stable reentry in a ring of cardiac tissue. J. Math. Biol. 55, 433–448 (2007). https://doi.org/10.1007/s00285-007-0100-z
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DOI: https://doi.org/10.1007/s00285-007-0100-z