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The Novel Antibacterial Peptide Ceratotoxin A Alters Permeability of the Inner and Outer Membrane of Escherichia coli K-12

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Abstract.

Ceratotoxins are antibacterial 3-kDa amphiphilic peptides isolated from the female reproductive apparatus of the medfly Ceratitis capitata. The antibacterial activity of a chemically synthesized ceratotoxin A (ctx A) has been investigated. Ctx A was mainly active against Gram-negative organisms, and it had a lytic effect on nongrowing Escherichia coli K-12. Data showed that ctx A alters both the outer and the inner membrane of E. coli K-12 cells.

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Authors and Affiliations

  1. Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena, Via Laterina 8, 53100 Siena, Italy , , , , , , IT

    Laura Marri

  2. Dipartimento di Biologia Evolutiva, Università di Siena, Via P.A. Mattioli 4, 53100 Siena, Italy , , , , , , IT

    Romano Dallai & Daniela Marchini

Authors
  1. Laura Marri
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  2. Romano Dallai
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  3. Daniela Marchini
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Received: 4 August 1995 / Accepted: 2 January 1996

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Marri, L., Dallai, R. & Marchini, D. The Novel Antibacterial Peptide Ceratotoxin A Alters Permeability of the Inner and Outer Membrane of Escherichia coli K-12. Curr Microbiol 33, 40–43 (1996). https://doi.org/10.1007/s002849900071

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  • DOI: https://doi.org/10.1007/s002849900071

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