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An Analysis of Biosynthesis Gene Clusters and Bioactivity of Marine Bacterial Symbionts

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Abstract

Symbiotic marine bacteria have a pivotal role in drug discovery due to the synthesis of diverse biologically potential compounds. The marine bacterial phyla proteobacteria, actinobacteria and firmicutes are commonly associated with marine macro organisms and frequently reported as dominant bioactive compound producers. They can produce biologically active compounds that possess antimicrobial, antiviral, antitumor, antibiofilm and antifouling properties. Synthesis of these bioactive compounds is controlled by a set of genes of their genomes that is known as biosynthesis gene clusters (BGCs). The development in the field of biotechnology and bioinformatics has uncovered the potential BGCs of the bacterial genome and its functions. Now-a-days researchers have focused their attention on the identification of potential BGCs for the discovery of novel bioactive compounds using advanced technology. This review highlights the marine bacterial symbionts and their BGCs which are responsible for the synthesis of bioactive compounds.

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Fig. 1
Fig. 2
Fig. 3

source platform Antismash (bacterial version 5.0). a Shows the BGCs detected in the genome of symbiotic and non-symbiotic Bacillus. b Reveals the variation of BGCs identified in symbiotic and non-symbiotic Bacillus. c Displays the difference between the numbers of antibiotic classes predicted from the BGCs of symbiotic and non-symbiotic Bacillus

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  1. Centre for Marine Science and Technology, Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari, Tamilnadu, India

    Nadarajan Viju & Stanislaus Mary Josephine Punitha

  2. Department of Marine Biology, Faculty of Marine Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

    Sathianeson Satheesh

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  1. Nadarajan Viju
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Viju, N., Punitha, S.M.J. & Satheesh, S. An Analysis of Biosynthesis Gene Clusters and Bioactivity of Marine Bacterial Symbionts. Curr Microbiol 78, 2522–2533 (2021). https://doi.org/10.1007/s00284-021-02535-4

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