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Cystic and Non-Cystic Fibrosis Pseudomonas aeruginosa Isolates are not Differentiated by the Quorum-Sensing Signaling and Biofilm Production

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Abstract

The capability for biofilm and quorum-sensing (QS) signaling production among Pseudomonas aeruginosa isolates were evaluated. A total of 231 isolates were recovered from sputa of cystic fibrosis (CF, n = 104) and non-CF (non-CF, n = 127) patients. One hundred ninety-seven (85.3%; 95% CI 80.1–89.3%) were biofilm producers and 157 (68%; 95% CI 61.7–73.6%) were weak QS-producing. No difference was observed between CF and non-CF isolates regarding the ability to produce biofilm and QS-signaling. Interestingly, the degree of QS production appears to be related to the degree of biofilm production. Thus, blocking QS pathways may be crucial in the prevention and treatment of biofilm-related infections.

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Acknowledgment

We acknowledge the technical support from Ana Lúcia Souza Antunes, Cristiane Regina Guerino Furini e Greice Catrine Goerck.

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Authors and Affiliations

  1. Pharmaceutical Sciences, Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, Porto Alegre, Brazil

    Leandro Reus Rodrigues Perez & Afonso Luís Barth

  2. Clinical Analysis Department, Faculdade de Farmácia, UFRGS, Porto Alegre, RS, Brazil

    Ana Lúcia Peixoto de Freitas & Afonso Luís Barth

  3. Microbiology Unit, Clinical Pathology Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

    Afonso Luís Barth

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  1. Leandro Reus Rodrigues Perez
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  2. Ana Lúcia Peixoto de Freitas
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  3. Afonso Luís Barth
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Correspondence to Leandro Reus Rodrigues Perez.

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Perez, L.R.R., de Freitas, A.L.P. & Barth, A.L. Cystic and Non-Cystic Fibrosis Pseudomonas aeruginosa Isolates are not Differentiated by the Quorum-Sensing Signaling and Biofilm Production. Curr Microbiol 64, 81–84 (2012). https://doi.org/10.1007/s00284-011-0041-z

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  • DOI: https://doi.org/10.1007/s00284-011-0041-z

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