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Plasma cytokines in graft vs host disease and complications following bone marrow transplantation

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Hematology and Cell Therapy

Abstract

A cohort of 201 autologous or allogeneic bone marrow transplanted (BMT) patients were included for studying the evolution of circulating tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) by means of repeated plasma determinations. IL-6 levels were high during major transplant-related complications (TRC) or severe graft vs host disease (GVHD). High levels of TNF-alpha seemed to be associated with chronic GVHD but not with acute GVHD or TRC.

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Authors and Affiliations

  1. Département de Biochimie Médicale et Biologie Moléculaire, Université de Bordeaux 2, 146, Rue Léo-Saignat, F-33076, Bordeaux Cedex, France

    A. N. Abdallah & A. Iron

  2. Unité de Greffe de Moelle, CHU de Bordeaux, Avenue Magellan, F-33604, Pessac, France

    J. M. Boiron & J. Reiffers

  3. Laboratoire de Biochimie, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie-Raba-Léon, F-33076, Bordeaux Cedex, France

    Y. Attia, A. Cassaigne & A. Iron

Authors
  1. A. N. Abdallah
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  2. J. M. Boiron
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  3. Y. Attia
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  4. A. Cassaigne
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  5. J. Reiffers
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  6. A. Iron
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Abdallah, A.N., Boiron, J.M., Attia, Y. et al. Plasma cytokines in graft vs host disease and complications following bone marrow transplantation. Hematol Cell Ther 39, 27–32 (1997). https://doi.org/10.1007/s00282-997-0027-2

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  • DOI: https://doi.org/10.1007/s00282-997-0027-2

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