References
Lerner AB, Barnura CP, Watson CJ (1947) Studies of cryoglobulins. II. Spontaneous precipttation of protein from serum at 5°C in various disease States. Am J Med Sei 214:416
Grey HM, Kohler PF (1973) Cryoimmunoglobulins. Semin Heraatol 10:87
Brauet JC, Clauvel JP, Danon F, Klein M, Seligmann M (1974) Biological and clinical significance of cryoglobulins. A report of 86 cases. Am J Med 57:775
Geltner D, Franklin EC, Frangione B (1980) Antiidiotypic activity in the IgM fractions of mixed cryoglobulins. J Immunol 125:1530
Reeves WH, Chiorazzi N (1986) Interaction between anti-DNA and anti-DNA-binding protein autoantibodies in cryoglobulins from sera of patients with systemic lupus erythematosus. J Exp Med 164:1029
Stone GC, Nardella FA, Oppliger IR, Mannik M (1988) Absence of auto-antiidiotypic activity between the IgM and IgG fractions of human mixed cryoglobulins. J Immunol 140:3114
Middaugh CR, Gerber-Jensen B, Hurvitz A, Paluszek A, Scheffel C, Litman GW (1978) Physicochemical characterization of six monoclonal cryoimmunoglobulins: possible basis for cold-dependent insolubility. Proc Natl Acad Sei USA 75:3440
Middaugh CR, Lawson EQ, Litman GW, Tisel WA, Mood DA, Rosenberg A (1980) Thermodynamic basis for the abnormal solubility of monoclonal cryoglobulins. Biol Chem 255:6532
Scoville CD, Turner DH, Lippert IL, Abraham GN (1980) Study of the kinetic and structural properties of a monoclonal immunoglobulin G cryoglobulin. I Biol Chem 255:5847
Tsai CM, Zopf DA, Yu RK, Wistar R Jr, Ginsburg V (1977) A Walderström macroglobulin that is both a cold agglutinin and a cryoglobulin because it binds N-acetylneuraminosyl residues. Proc Natl Acad Sei USA 74:4591
Weber RJ, Clem LW (1981) The molecular mechanism of cryopreeipitation and cold agglutination of an IgM η Waldenström macroglobulin with anti-Gd speeificity: Sedimentation analysis and localization of interacting sites. Immunol 127:300
Patel RD, Brown JC (1985) Preparation and characterization of murine monoclonal antibodies that express both cold agglutinin and cryoglobulin activities. J Immunol 134:4041
Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JfB, Dixon FJ (1978) Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198
Abdelmoula M, Spertini F, Shibata T, Gyotoku Y, Luzuy S, Lambert PH, Izui S (1989) IgG3 is the major source of cryoglobulins in mice. J Immunol 143:526
Gyotoku Y, Abdelmoula M, Spertini F, Izui S, Lambert PH (1987) Cryoglobulinemia induced by monoclonal immunoglobulin G rheumatoid factors derived from autoimmune MRL/MpJ-lpr/lpr mice. J Immunol 138:3785
Lemoine R, Berney T, Shibata T, Fulpius T, Gyotoku Y, Shimada H, Sawada S, Izui S (1992) Induction of “wire-loop” lesions by murine monoclonal IgG3 cryoglobulins. Kidney Int 41:65
Delinho RA, Feldman LB, Scharff MD (1986) Tailor-made monoclonal antibodies. Ann Intern Med 104:225
Fulpius T, Spertini F, Reininger L, Izui S (1993) Immunoglobulin heavy chain constant region determines the pathogenicity and the antigen-binding activity of rheumatoid factor. Proc Natl Acad Sei USA 90:2345
Moll S, Menoud PA, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli JD, Sappino AP, Schifferti JA, Izui S (1995) Induction of plasminogen activator inhibitor type I in murine lupus-like glornerulonephritis. Kidney Int 48:1459
Spertini F, Coulie PG, Van Snick J, Davidson E, Lambert PH, Izui S (1989) Inhibition of cryoprecipitation of murine IgG3 anti-dinitropheny] (DNP) monoclonal antibodies by anionic DNP-amino acid conjugates. Eur J Iramunol 19:273
Schluesener H, Brunner C, Vass K, Lassmann H (1986) Therapy of rat autoimmune disease by a monoclonal antibody specific for T lymphoblasts. J Immunol 137:3814
Takahashi S, Itoh J, Nose M, Ono M, Yamarnoto T, Kyogoku M (1993) Cloning and cDNA sequence analysis of nephritogenic monoclonal antibodies derived from an MRL/lpr lupus mouse. Mol Immunol 30:177
Rengers JU, Touchard G, Decourt C, Deret S, Michel H, Cogné M (2000) Heavy and light chain primary structures control IgG3 nephritogenicity in an experimental model for cryocrystalglobulinemia. Blood 95:3467
Grey HM, Hirst JW, Cohn M (1971) A new mouse immunoglobulin: IgG3. J Exp Med 133:289
Berney T, Fulpius T, Shibata T, Reininger L, Van Snick J, Shan H, Weigert M, Marshak-Rothstein A, Izui S (1992) Selective pathogenicity of murine rheumatoid factors of the cryoprecipitable IgG3 subclass. Int Immunol 4:93
Wels JA, Word CJ, Rimm D, Der-Balan GP, Martinez HM, Tucker PW, Blattner FR (1984) Structural analysis of the murine IgG3 constant region gene. EMBO J 3:2041
Panka DJ (1997) Glycosylation is influential in murine IgG3 self-association. Mol ImmunoJ 34:593
Grey HM, Kohler PF, Terry WD, Franklin EC (1968) Human monoclonal γG-cryoglobulins with anti-γ-globulin activity. J Clin Invest 447:1875
Capra JD, Kunkel HG (1970) Aggregation of γG3 proteins: relevance to the hyperviscosity syndrome. J Clin Invest 49:610
Saluk PH, Clem W (1975) Studies on the cryoprecipitation of a human IgG3 cryoglobulin: the effects of temperature-induced conformational changes on theprimary interaction. Immunochemistry 12:29
Nishimura Y, Nakamura H (1984) Human monoclonal cryoimmunoglobulins. I. Molecular properties of IgG3k (Jir protein) and the cryo-coprecipitability of its molecular fragments by papain. J Biochem 95:255
Spertini F, Donati Y, Welle I, Izui S, Lambert PH (1989) Prevention of murine cryoglobulinemia and associated pathology by monoclonal anti-idiotypic antibody. J Immunol 143:2508
Middaugh CR, Litman GW (1987) Atypical glycosylation of an IgG monoclonal cryoimmunoglobulin. J Biol Chem 262:3671
Lawson EQ, Brandau DT, Trauman PA, Middaugh R (1988) Electrostatic properties of cryoimmunoglobulins. J Immunol 140:1218
Panka DJ, Salant DJ, Jacobson BA, Minto AW, Marshak-Rothstein A (1995) The effect of VH residues 6 and 23 on IgG3 cryoprecipitation and glomerular deposition. Eur J Immunol 25:279
Parekh RB, Dwek RA, Sutton BJ, Fernandes DL, Leung A, Stanworth D, Rademacher TW, Mizuochi T, Taniguchi T, Matsuta K, Takeuchi F, Nagano Y, Miyamoto T, Kobata A (1985) Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316:452
Parekh R, Isenberg D, Rook G, Roitt I, Dwek R, Rademacher T (1989) A comparative analysis of disease-associated changes in the glycosylation of serum IgG. J Autoimm 2:101
Mizuochi T, Hamako J, Nose M, Titani K (1990) Structural changes in the oligosaccharide chains of IgG in autoimmune MRL/Mp-lpr/lpr mice. J Immunol 145:1794
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M, Fossati-Jimack L, Reininger L, Matsushita M, Fujita T, Izui S (2001) Role of galactosylation in the renal pathogenicity of murine IgG3 monoclonal eryoglobulins. Blood 97:3537
Axford JS, Lydyard PM, Isenberg DA, Mackenzie L, Hay FC, Roitt IM (1987) Reduced B-cell galactosyltransferase activity in rheumatoid arthritis. Lancet II: 1486
Furukawa K, Matsuta K, Takeuchi F, Kosuge E, Miyamoto T, Kobata A (1990) Kinetic study of a galactosyltransferase in the B cells of pattents with rheumatoid arthritis. Int Immunol 2:105
Axford JS, Alavi A, Bond A, Hay FC (1994) Differential B lymphocyte galactosyltransferase activity in the MRL mouse model of rheumatoid arthritis. Autoimmuity 17:157
Reininger L, Berney T, Shibata T, Spertini F, Merino R, Izui S (1990) Cryoglobulinemia induced by a murine IgG3 rheumatoid factor: skin vasculitis and glomerulonephritis arise from distinct pathogenic mechanisms. Proc Natl Acad Sei USA 87:10038
IzuiS, Fulpius T, Reininger L, Pastore Y, Kobayakawa T (1998) Role of neutrophiJs in murine cryoglobulinemia. Inflamm Res 47:S145
Verroust P, Morel-Maroger L, Preud’homme JL (1982) Renal lesions in dysproteinemias. Springer Semin Iramunopathol 5:333
Bernstein KA, Valerio RD, Lefkowith JB (1995) Glomerular binding aciivity in MRL lpr serum consists of antibodies that bind to a DNA/histone/type IV Collagen complex. J Immunol 154:2424
Mohan C, Morel L, Yang P, Watanabe H, Croker B, Gilkeson G, Wakeland EK (1999) Genetic dissection of lupus pathogenesis: arecipe for nephrophilic autoantibodies. J Clin Invest 103:1685
Foster MH, Cizman B, Madaio MP (1993) Biology of disease. Nephritogenic autoantibodies in systemic lupus erytheraatosus: irnmunochemical properties, mechanisrns of immune deposition, and genetic origins. Lab Invest 69:494
Fulpius T, Lemoine R, Berney T, Pastore Y, Moll S, Izui S (1996) Polymorphonuclear leukocytes play a key role in the generation of “wire-toop” lesions induced by a murine IgG3 rheumatoid factor. Kidney Int 49:647
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FMA, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS, Izui S (2000) Markedly different pathogenicity of four IgG isotype-switch variants of an anti-erythrocyte autoantibody is based on their respective capacity to interact in vivo with the low-affinity FcγRIII. J Exp Med 191:1293
Sylvestre DL, Ravetch JV (1994) Fc receptors initiate the Arthus reaction: redefming the inflarnmatory cascade. Science 265:1095
Sylvestre DL, Ravetch JV (1996) A dominant role for mast cells Fc receptors in the Arthus reaction. Immunity 5:387
Watanabe N, Akikusa B, Park SY, Ohno H, Fossati L, Vecchietri G, Gessner JE, Schmidt RE, Verbeek JS, Ryffel B, Iwamoto I, Izui S, Saito T (1999) Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fcγ receptors. Blood 94:3855
Clynes R, Dumitru C, Ravetch JV (1998) Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis. Science 279:1052
Takabashi S, Nose M, Sasaki J, Yamamoto T, Kyogoku M (1991) IgG3 production in MWL/lpr mice is responsible for development of lupus nephritis. J Immunol 147:515
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry JP, Nose M, Spach C, Motta R, Izui S (1993) An MRL/MpJ-/lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Int Immunol 5:525
Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S (1996) Imbalance towards Thl predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97:1597
Fulpius T, Berney T, Lemoine R, Pastore Y, Reininger L, Bdghouse G, Izui S (1994) Glomerulopathy induced by IgG3 anti-trinitrophenyl monoclonal cryoglobulins derived from non-autoimmune mice. Kidney Int 45:962
Diamond B, Yelton DE (1981) A new Fc receptor on mouse macrophages binding IgG3. J Exp Med 153:514
Yuan R, Clynes R, Ravetch JV, Scharff MD (1998) Antibody-mediated modulation of Cryptococcus neoformans infection is dependent on distinct Fc receptor functions and IgG subclasses. J Exp Med 187:641
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pastore, Y., Lajaunias, F., Kuroki, A. et al. An experimental model of cryoglobulin-associated vasculitis in mice. Springer Semin Immunopathol 23, 315–329 (2001). https://doi.org/10.1007/s002810100075
Issue Date:
DOI: https://doi.org/10.1007/s002810100075