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Tolerogenic dendritic cells

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Abstract

Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a tolerogenic function, participating in the enforcement of central and peripheral tolerance and the resolution of ongoing immune responses. Thus, DCs control effector and regulatory mechanisms relevant to the pathology of autoimmune disorders. In this review, we discuss recent findings regarding the control of the adaptive immune response by tolerogenic DCs. A thorough understanding of the mechanisms that control the tolerogenic DC phenotype will guide the development of novel strategies for the treatment of autoimmunity.

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Acknowledgments

Research in the Quintana laboratory is supported by the National Institutes of Health, the National Multiple Sclerosis Society, the International Progressive MS Alliance, and the American Cancer Society.

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Authors and Affiliations

  1. Ann Romney Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA

    Maisa C. Takenaka & Francisco J. Quintana

  2. Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA

    Francisco J. Quintana

Authors
  1. Maisa C. Takenaka
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  2. Francisco J. Quintana
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Correspondence to Francisco J. Quintana.

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This article is a contribution to the special issue on Dendritic Cell Subsets and Immune-mediated Diseases - Guest Editor: Francisco Quintana

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Takenaka, M.C., Quintana, F.J. Tolerogenic dendritic cells. Semin Immunopathol 39, 113–120 (2017). https://doi.org/10.1007/s00281-016-0587-8

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  • DOI: https://doi.org/10.1007/s00281-016-0587-8

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