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JAM-related proteins in mucosal homeostasis and inflammation

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Abstract

Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a molecular level, the mucosal barrier is regulated by tight junctions (TJs) that seal the paracellular space between adjacent epithelial cells. Transmembrane proteins within TJs include junctional adhesion molecules (JAMs) that belong to the cortical thymocyte marker for Xenopus family of proteins. JAM family encompasses three classical members (JAM-A, JAM-B, and JAM-C) and related molecules including JAM4, JAM-like protein, Coxsackie and adenovirus receptor (CAR), CAR-like membrane protein and endothelial cell-selective adhesion molecule. JAMs have multiple functions that include regulation of endothelial and epithelial paracellular permeability, leukocyte recruitment during inflammation, angiogenesis, cell migration, and proliferation. In this review, we summarize the current knowledge regarding the roles of the JAM family members in the regulation of mucosal homeostasis and leukocyte trafficking with a particular emphasis on barrier function and its perturbation during pathological inflammation.

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Acknowledgements

The authors acknowledge funding from The NIH (DK072564, DK061379, DK079392, DK064399, DK059888, and DK055679) and DOD (PR121194).

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  1. Epithelial pathobiology and mucosal inflammation research unit, Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, 30306, Atlanta, GA, USA

    Anny-Claude Luissint, Asma Nusrat & Charles A. Parkos

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  1. Anny-Claude Luissint
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Correspondence to Charles A. Parkos.

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This article is a contribution to the special issue on New paradigms in leukocyte trafficking, lessons for therapeutics - Guest Editors: F. W. Luscinskas and B. A. Imhof

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Luissint, AC., Nusrat, A. & Parkos, C.A. JAM-related proteins in mucosal homeostasis and inflammation. Semin Immunopathol 36, 211–226 (2014). https://doi.org/10.1007/s00281-014-0421-0

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