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Dendritic cells in atherosclerosis

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Abstract

Atherosclerosis is a chronic inflammatory disease with activation of both the innate and adaptive arms of the immune system. Dendritic cells (DCs) are potent activators of adaptive immunity and have been identified in the normal arterial wall and within atherosclerotic lesions. Recent evidence points to a functional role for DCs in all stages of atherosclerosis because of their myriad functions including lipid uptake, antigen presentation, efferocytosis, and inflammation resolution. Moreover, DC-based vaccination strategies are currently being developed for the treatment of atherosclerosis. This review will focus on the current evidence as well as the proposed roles for DCs in the pathogenesis of atherosclerosis and discuss future therapeutic strategies.

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Acknowledgments

I.T. is supported by National Institutes of Health grants HL106019, HL075662, and HL054591.

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Authors and Affiliations

  1. Department of Medicine, Columbia University, 630 West 168th Street PH9-406, New York, NY, 10032, USA

    Manikandan Subramanian & Ira Tabas

  2. Department of Pathology and Cell Biology, Columbia University, 630 West 168th Street PH9-406, New York, NY, 10032, USA

    Ira Tabas

  3. Department of Physiology, Columbia University, 630 West 168th Street PH9-406, New York, NY, 10032, USA

    Ira Tabas

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  1. Manikandan Subramanian
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Correspondence to Manikandan Subramanian.

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This article is a contribution to the special issue on Metabolic Syndrome - Guest Editor: T. Miyazaki

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Subramanian, M., Tabas, I. Dendritic cells in atherosclerosis. Semin Immunopathol 36, 93–102 (2014). https://doi.org/10.1007/s00281-013-0400-x

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