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Monocyte heterogeneity in cardiovascular disease

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Abstract

Only a few decades ago, students of the pathophysiology of cardiovascular disease paid little heed to the involvement of inflammation and immunity. Multiple lines of evidence now point to the participation of innate and adaptive immunity and inflammatory signaling in a variety of cardiovascular conditions. Hence, interest has burgeoned in this intersection. This review will focus on the contribution of innate immunity to both acute injury to the heart muscle itself, notably myocardial infarction, and to chronic inflammation in the artery wall, namely atherosclerosis, the cause of most myocardial infarctions. Our discussion of the operation of innate immunity in cardiovascular diseases will focus on functions of the mononuclear phagocytes, with special attention to emerging data regarding the participation of different functional subsets of these cells in cardiovascular pathophysiology.

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA

    Peter Libby

  2. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Matthias Nahrendorf & Filip K. Swirski

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  1. Peter Libby
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  2. Matthias Nahrendorf
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  3. Filip K. Swirski
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Correspondence to Peter Libby.

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This article is a contribution to the special issue on Macrophage Heterogeneity, Subsets and Human Disease - Guest Editor: Siamon Gordon

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Libby, P., Nahrendorf, M. & Swirski, F.K. Monocyte heterogeneity in cardiovascular disease. Semin Immunopathol 35, 553–562 (2013). https://doi.org/10.1007/s00281-013-0387-3

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